Study of an injectable in situ forming gel for sustained-release of Ivermectin in vitro and in vivo

Z, Geng; Luo, Xingqi; Zhang, Zhenrui; Li, Huimin; Tian, Jing; Yu, Zugong

doi:10.1016/j.ijbiomac.2015.12.028

Cited by 16 publications

(15 citation statements)

References 43 publications

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“…Thus, show a slow in vitro release rate with a burst release of 10.46% and 80% where the cumulative release is within 80 days. As for pharmacokinetic results show the concentration of effective blood on the gel can be maintained up to 110 to 120% (Geng et al, 2016).…”

Section: Saib-pla Combination Gel Forming Agent Formulationmentioning

confidence: 97%

“…The use of in situ gel-forming using gum gel can be used for drugs for vaginal use purposes, wherein research conducted by Patel, and Patel in 2015, obtained test results from gum gellan formulations combined with the active substance clindamycin, showing improved texture characteristic results seen from rheological results. The addition of HPMC to the formulation is useful to reduce the sole at the gel transition temperature, as well as also used to affect the mucoadhesive Formulations can be used (Geng et al, 2016) ( Kurniawansyah et al, 2018).…”

Section: Gel Forming Agent Formulation Gel Combination Gellan Gummentioning

confidence: 99%

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The Advantages of In situ Gel from Every Different Formulation

Sopyan¹,

Intani²,

S³

et al. 2020

ijrps

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The in situ gel system is one of the polymer-based solutions that show the sol phase transition to gel. In addition to being used to improve bioavailability, this gel is also used to make the drug increase the residence time in the area of use, so that it can provide maximum effectiveness via enhancing of per cent permeation, The use of in situ gel, usually used in ocular administration of drugs, for the treatment of cancer, administration of drugs in the vaginal, rectal, topical, oral, and any route administration. There are many formulations of in situ gel formation that are used for medicinal preparations for many purposes, with different lengths of stay. Searching for articles is done online, browsing the PubMed and Google scholar site with the keyword "Formulation In situ Gel". The fourty articles used, there were 40 in situ gel formulations with gelling agents and also different uses. The purpose of this article review is to look at the superiority of in situ gel formulations and to compare various in situ gel formulations studied from 40 articles used, so that it can be seen which formulation is most often used and has a good effect on drugs preparations.

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Section: Saib-pla Combination Gel Forming Agent Formulationmentioning

confidence: 97%

Section: Gel Forming Agent Formulation Gel Combination Gellan Gummentioning

confidence: 99%

The Advantages of In situ Gel from Every Different Formulation

Sopyan¹,

Intani²,

S³

et al. 2020

ijrps

View full text Add to dashboard Cite

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“…The solution to these problems focussed on two aspects. One is shrinking the gelation time after administration, such as increasing the gelator concentration, modifying gelator structure or adding crosslinker [24][25][26]. The other is preloaded the drug into some vesicles such as microemulsions, nanoparticles or microspheres [27,28].…”

Section: Introductionmentioning

confidence: 99%

Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology

Yan

Sun

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box-Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system.

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“…Significant advantages of the SABER system are a reduction in the amount of organic solvent, ease of use, lower production costs, and excellent sustained-release behavior that can be adjusted by additives from a few days to several months (Okumu et al., 2002 ). The most commonly used additives are biocompatible polymers, such as polylactic acid (PLA) and poly(d,l-lactide-co-glycolide) (PLGA) (Lu et al., 2008 ; Lin et al., 2012 ; Geng et al., 2016 ). However, there are few reports about the application of SABER systems in long-lasting delivery of bioactive polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation

Wang

Zheng

et al. 2018

Drug Delivery

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This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP. When the ‘90%SAIB/10% solvent’ system was used, the mean residence time (MRT) of ROP was prolonged by 4.3 5 ∼ 7.00 times and the initial release rate was reduced significantly. However, this system was only suitable for days-long sustained release of ROP in short-term therapy. As to the ‘SAIB/additives/solvent’ system containing mono-PEGylated ROP, the results indicated that SAIB/poly(d,l-lactide-co-glycolide) (PLGA)/N-methyl-2-pyrrolidone (NMP) was superior to SAIB/polylactic acid (PLA)/NMP and SAIB/PLA/ethanol in controlled release. Moreover, weeks- to months-long (16–60 d) smooth release of ROP could be achieved by varying the concentration (10–30%) and molecular weight (MW) of PLGA (10–50 kDa) or by employing a moderate MW of PEGylated ROP (∼20 or ∼30 kDa). With further increasing the conjugate MW to ∼40 kDa, the contribution of drug elimination to its plasma retention seemed to surpass that of the SAIB-based system, resulting in that the system no longer had an obvious influence on the in vivo behavior of the conjugate. Besides, the results of host response confirmed that with less solvent being used, the SAIB-based systems showed a higher biocompatibility than the PLGA-based systems, suggesting that they could be freely chosen in the prevention and/or cure of chronic diseases.

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Study of an injectable in situ forming gel for sustained-release of Ivermectin in vitro and in vivo

Cited by 16 publications

References 43 publications

The Advantages of In situ Gel from Every Different Formulation

The Advantages of In situ Gel from Every Different Formulation

Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology

Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation

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