Study of acute encephalitis syndrome in children

Abstract

Objective: To determine the profile and outcome of children admitted with Acute Encephalitis Syndrome (AES) and to find out the prevalence of Japanese Encephalitis (JE) IgM antibodies positive cases among these patients with their case fatality rate (CFR). Materials and methods: Study consist of retrospective analysis of hospital records of children up to 15 years of age admitted with diagnosis of AES in pediatric wards of College of Medical Sciences-Teaching Hospital, Bharatpur from January 2007 to December 2008. Results: During two years, 61 patients of AES were admitted. Male and female patients were 33 and 28 respectively. Meningitis accounted for 29 and encephalitis for 32 patients. JE IgM seropositive cases contributed for 18% of all AES cases. Case fatality for JE was 16.6%. Conclusions: Japanese Encephalitis is endemic in catchment area of the hospital. JE has significant morbidity and mortality which can be prevented by immunization and mortality can be reduced if supportive interventions are provided in time. Key words: AES; JE; CFR. DOI: 10.3126/jcmsn.v6i1.3596 Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 7-13

Clinical Profile of Acute Encephalitis Syndrome in Children with Special Reference to Japanese Encephalitis in a Tertiary Care Teaching Hospital of Upper Assam

“…The most common affected age group is 5-12 years comprising 64.8% (n=105) of cases which is similar to that of other studies (Kakoti, Dutta et al [13] , Khinchi et al [17] , De et al [18] ). However Roy et al from Kolkata reported 71.4% cases in the 1mon-7 years age group.…”

A clinico-epidemiological profile of acute encephalitis syndrome in children of Bellary, Karnataka, India

“…Out of 136 AES suspects, 115 (84.5%) have been suspected for viral etiology including J.E and Dengue, 11 (9.5%) of them were suspected of AES-other agents like non-viral (bacteria) and 8 (5.8%) cases were suspected for AES of unknown etiology (Table 5). 14,15 Whereas there was equal distribution of cases among both the sexes and higher proportion of cases were in the age-group of 5-12 years in studies conducted by Kabilan L et al and Sharma J et al 16,17 In our study the seasonal occurrence of AES cases was peak during post-monsoon(October -February) and out of five JE positive cases two occurred in September, one in October and two in November each respectively. which was similar with findings in study by Khinchi YR et al, Anuradha et al however a difference in pattern of seasonal distribution of AES-JE cases was seen in studies by Kabilan L et al, JE occurrence was perennial, with a peak in the month of December and in a study by Sarkar et al found that cases were more in the monsoon and post-monsoon period.…”

“…which was similar with findings in study by Khinchi YR et al, Anuradha et al however a difference in pattern of seasonal distribution of AES-JE cases was seen in studies by Kabilan L et al, JE occurrence was perennial, with a peak in the month of December and in a study by Sarkar et al found that cases were more in the monsoon and post-monsoon period. 15,16,18,19 This difference in observations may be due to ecological variations of distribution of Culex mosquitoes. However, this was enumerated with the results obtained in an ecological study by Kanojia PC on mosquito vectors of Japanese encephalitis virus in Bellary district, Karnataka at National Institute of Virology(ICMR), Pune, where the general mosquito population showed bimodal pattern of peak occurrence.…”

Japanese Encephalitis in Children in Bellary Karnataka: Clinical Profile and Sequelae

“…Among the infectious agents viruses top the list [1,2] .Japanese Encephalitis (JE) is the most prevalent and important mosquito borne viral encephalitis of man in the world in terms of morbidity and mortality with an estimated 50,000 cases and 10,000-15,000 deaths annually [3,4,5] . The disease commonly affects children [3] .…”