Study of Acute Dermal Toxicity of Sodium-Containing Drugs

Abstract

To date, special attention should be paid to drugs that have antimicrobial, anti-inflammatory and wound-healing effects, one of which is sodium-containing drugs.
 The article presents the results of experimental studies to study the acute toxicity of sodium-containing drugs: glycetinate 2 %, its analogues – ovocid 2 %, ovocid 3 %, potassium-sodium 1.5% (Na/K 1.5 %). The study of acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 animals in each were formed: rats of group I on the skin was applied ovocid 3 %, group 2 - Nа/К 1,5 %, 3rd group - ovocid 2 %, and the 4th group of rats (control) was applied glycetinate 2 %. The animals were subjected to clinical observations, assessing their general condition and skin reaction. The effect of drugs on morphological and biochemical parameters of blood of rats was studied.
 The studied drugs did not cause visible disorders of physiological functions, the appearance of clinical signs of intoxication. There were no significant clinical signs of inflammation or irritation (erythema, edema and cracks) on the skin of the animals, but there was a slight redness at the application site, which later disappeared.
 The studied sodium-containing preparations (ovocid 3 %, Nа/К 1,5 %, ovocid 2 %, glycetinate 2 %) under the conditions of a single application of the preparation to the skin of animals did not cause the death of animals, which allows us to classify these preparations as low-toxic substances.