Study of acute and subacute action of iron-molybdenum nanocluster polyoxometalates

Abstract

Abstract-There were no significant deviations from the norm in the functional state of the liver, kidneys, and pancreas in the study of the acute toxicity of iron-molybdenum buckyballs intended for targeted drug deliv ery. No accumulation of nanoparticles or deviation from the norm in any investigated parameter was detected in the study of subacute toxicity.

Electrotransport, sorption, and photochemical properties of nanocluster polyoxomolybdates with a toroidal structure

“…In [1][2][3][4][5][6][7][8], we studied physical and chemical proper ties of nanocluster polyoxometalates (POM) based on the structure of molybdenum of the keplerate type (buckyball, fullerene), including electrotransport, sorption, photochemical and thermal stability, and complexation. These compounds were first obtained by Prof. Müller in Germany [9,10].…”

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

“…Toxicity studies did not reveal any significant adverse effect of Mo 72 Fe 30 on the animal subjects [344]. Studies of the acute and subacute effects of Mo 72 Fe 30 on the functional status of such organs of experimental animals as the liver, kidneys, and pancreas, confirmed the absence of appreciable negative effects [345,346]. In addition, the available experimental data on the effects of Mo 72 Fe 30 on liver and blood cells [347] suggest that this nanocluster does not cause the autoimmune reaction of lymphocytes to hepatocytes.…”

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

“…The very first experimental results showed that these ideas are promising. The low toxicity of Keplerate POMs for the warm-blooded animals, in particular of the iron-containing compounds, has been established on the basis of a set of data [132][133][134][135][136][137]. When studying the acute and subacute effects of Mo 72 Fe 30 on rats, no significant negative changes in internal organs were revealed.…”

“…A sharp decrease in the content of molybdenum in the kidneys was found, the cause of which is, apparently, the excretion of the excessive amount of this element via the urinary tract. Experiments with the Mo 72 Fe 30 polyoxometalate [132,133,137] administered at the same dosage, made it possible to establish for this POM the absence of accumulation of molybdenum in the liver, kidneys, bones, and skin of animals, including its hairy part and subcutaneous fatty tissue, since the average values of molybdenum content in the experimental samples after the termination of the procedures did not differ significantly from those in the intact animals. The histological analysis [132,137] of animal organs [138] and the results of hematologic studies [134] indicated a relatively higher toxicity of Mo 132 as compared to Mo 72 Fe 30 .…”