Study of Abnormal Liver Function Test during Pregnancy in a Tertiary Care Hospital in Chhattisgarh

Abstract

Introduction Abnormal liver function tests (LFTs) in pregnancy require proper interpretation in order to avoid pitfalls in the diagnosis. The underlying disorder can have a significant effect on the outcome of both mother and foetus. The present study was done with the objective to study the clinical profile, incidence and possible causes of derangements of liver function tests. Material and Method Eighty pregnant women with abnormal liver dysfunction were studied prospectively. Women with chronic liver disease and drug-induced abnormal liver function test were excluded. All available LFTs including LDH were studied along with some more definitive tests to aid identification of underlying cause. Foetomaternal outcome was noted in all. Result The incidence of abnormal LFT was 0.9 %. 13/80 (16.75 %) women had liver disorder not specific to pregnancy, whereas 67/80 (83.25 %) women had pregnancyspecific liver dysfunction. Of these, 65(81.25 %) women 123 with liver dysfunction had pre-eclampsia including 11 (13.75 %) with HELLP and six women with eclampsia. 48/65 (60 %) women had pre-eclampsia in the absence of HELLP syndrome or eclampsia.

A study of spectrum and outcome of liver diseases in pregnant women at BRD medical college

“…[10][11][12] In present study, 86% of affected patients had pregnancy-specific liver disease. This is similar to finding of 83.25% in study by Nalini et al and 76% in study by CL Ch'ng et al 13,1 In our study, 14.02 % women had liver disorders which were not specific to pregnancy and consisted of infective hepatitis and others (cause could not be found). In present study Hepatitis-B was the cause in all cases of chronic liver disease.…”

“…6 Many studies are with lower maternal mortality in comparision to our study. 3,6,9,13 In the present study, HELLP syndrome developed in 15.62% of patients. In which 28 out of 30 were in women with Hypertensive disorders of pregnancy and 2 in women with AFLP.…”

“…These finding are also comparable with other two studies. 9,13 In the present study 32.29 % babies were premature, still birth was 16.14%, IUD were 13.54%, Early neonatal death was in 13.02%. NICU admission was required in 24.47% newborns.…”

“…This is in accordance with result of various prospective studies in India. 3,5,13 Few other Indian studies, one by Umang R et al in Mumbai and other prospective study by Divyakala et al in Karnataka showed much higher incidence of HELLP Syndrome (61.11% and 75.68% respectively). In our setting DIC developed in 47 (24.48%) patients, while Acute renal failure and Hepatic Encephalopathy developed in 28 (15.58%) and 7 (3.64%) of Patients with liver disease respectively.…”

Jaundice and Pregnancy: Why Going Viral Is Out of Style

“…While the authors identify gallstone-related disease as the most common cause of hyperbilirubinemia, the preponderance of a Hispanic population in this study raises the question of whether these findings would apply to a broader-based US population. Pregnancy-related disease, the second most common etiology in the current study, is by far the most common cause in Europe and Asia [6][7][8]. Further, gallstone-related disease is much less frequent outside of the USA.…”