Study of a (trimethylenecarbonate-co-ε-caprolactone) polymer—Part 1: preparation of a new nerve guide through controlled random copolymerization using rare earth catalysts

Schappacher, Michel; Fabre, Thierry; Mingotaud, Anne‐Françoise; Soum, Alain

doi:10.1016/s0142-9612(01)00029-1

Cited by 96 publications

(83 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the molecular weights and molecular weight distributions of the resulting polymers were almost unchanged (Table I entries [3][4][5][6][7][8]. The increase in the initiator concentration led to the increase in polymer yield, the decrease of M n of the resulting polymer, while the polydispersity of PTMC remained rela- tively broad and kept almost unchanged (Table II entry 1-4).…”

Section: Homopolymerization Of Tmcmentioning

confidence: 99%

Ring‐opening polymerization of trimethylenecarbonate and its copolymerization with ϵ‐caprolactone by lanthanide (II) aryloxide complexes

Zhao

Shen

2007

J of Applied Polymer Sci

View full text Add to dashboard Cite

Lanthanide metal (II) 2,6-di-tert-butylphenoxide complexes (ArO) 2 Ln(THF) 3 (Ln 5 Sm 1, Yb 2) alone have been developed to catalyze the ring-opening polymerization of trimethylenecarbonate (TMC) and random copolymerization of TMC and e-caprolactone (e-CL) for the first time. The influence of reaction conditions, such as initiator, initiator concentration, polymerization temperature, and polymerization time, on monomer conversion, molecular weight, and molecular weight distribution of the resulting PTMC was investigated. It was found that the divalent complex 1 showed higher activity for the polymerization of TMC than complex 2. The random structure and thermal behavior of the copolymers P(TMC-co-CL) have been characterized by 1 H NMR, 13 C NMR, GPC, and DSC analysis.

show abstract

Section: Homopolymerization Of Tmcmentioning

confidence: 99%

Ring‐opening polymerization of trimethylenecarbonate and its copolymerization with ϵ‐caprolactone by lanthanide (II) aryloxide complexes

Zhao

Shen

2007

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…This has been implication in the stimulation of inflammatory reactions as well as deactivation of proteins in the surrounding tissue [99]. Therefore, this has led to the development of copolymers of the lactides/glycolides with other monomers to form poly(ether esters), poly(ester carbonates), poly(ester amides) and poly(ester urethanes) [100][101][102][103][104][105].…”

Section: Natural Materialsmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

View full text Add to dashboard Cite

The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. Acellular scaffolds preserve the microarchitecture of articular cartilage through a process of decellularization of biological tissue. Although promising, this technique often results in poor biomechanical strength of the graft. However, biomechanical strength could be improved if biomaterials could be incorporated back into the decellularized tissue to overcome this limitation.

show abstract

“…Although PCL is a semicrystalline polyA C H T U N G T R E N N U N G mer with a glass transition temperature (T g ) of À66 8C, PTMC (T g = À15 8C) is rather amorphous. [31] Furthermore, because ester bonds are more sensitive to hydrolysis than carbonates, which are almost totally resistant, PCL degrades faster than PTMC. [4,5,9] Thus, copolymerization of TMC and CL enables tuning of the physical properties (e.g., morphology, crystallinity) and the degradation behavior of the resulting material, and thereby facilitates access to tailor-made biopolymers.…”

Section: A C H T U N G T R E N N U N G (Ch 2 ) 3 Oc(o)hmentioning

confidence: 99%

“…[32] In addition, copolymers of CL can exhibit a wide range of elasticity and softness, two features that might be required simultaneously within a biomaterial such as a guide for in vivo nerve reconstruction. [31,33] Some PTMC-PCL copolymers have been synthesized from various rare-earth halide (LnX 3 /epoxide or isopropoxide) or alkoxide ("LnA C H T U N G T R E N N U N G (OiPr) 3 …”

Section: A C H T U N G T R E N N U N G (Ch 2 ) 3 Oc(o)hmentioning

confidence: 99%

Unprecedented Polymerization of Trimethylene Carbonate Initiated by a Samarium Borohydride Complex: Mechanistic Insights and Copolymerization with ε‐Caprolactone

Palard

Schappacher

Belloncle

et al. 2007

Chemistry A European J

106

View full text Add to dashboard Cite

Poly(trimethylene carbonate) (PTMC) was synthesized through ring-opening polymerization by using a rare-earth borohydride initiator, [Sm(BH(4))(3)(thf)(3)]. This initiator shows a high activity to give high-molar-mass PTMCs with molar-mass distributions ranging from 1.2 to 1.4, and with a regular structure void of ether linkages. The polymers were characterized by (1)H and (13)C NMR spectroscopy, (1)H-(1)H COSY, (1)H-(13)C HMQC NMR spectroscopy, size-exclusion chromatography (SEC), viscosimetry, and MALDI-TOF MS analyses. A coordination-insertion mechanism was established based on detailed NMR characterizations, especially of the polymer chain end-functions. The monomer initially coordinates the samarium to give [Sm(BH(4))(3)(tmc)(3)], 1. The monomer then opens up through cleavage of the cyclic ester oxygen--acyl bond and inserts into the Sm--HBH(3) bond resulting in an alkoxide complex, [Sm{O(CH(2))(3)OC(O)HBH(3)}(3)], 2, or [Sm{O(CH(2))(3)OC(O)H}(3)], 2', which then propagates the polymerization of TMC to give the active polymer [Sm({O(CH(2))(3)OC(O)}(n)O(CH(2))(3)OC(O)HBH(3))(3)], 3 or [Sm(O(CH(2))(3)OC(O){O(CH(2))(3)OC(O)}(n)O(CH(2))(3)OC(O)H)(3)], 3'. Finally, acidic hydrolysis of 3 or 3' gives HO(CH(2))(3)OC(O)[O(CH(2))(3)OC(O)](n)O(CH(2))(3)OC(O)H, 4. This novel alpha-hydroxy,omega-formatetelechelic PTMC represents the first example of a formate-terminated polycarbonate. TMC and epsilon-caprolactone (CL) were copolymerized to afford both random PTMC-co-PCL and block PTMC-b-PCL copolymers that were characterized by (1)H NMR spectroscopy, SEC, and differential scanning calorimetry (DSC). The structure of the block copolymers depends on the order of addition of monomers: if CL is introduced first, dihydroxytelechelic HO-PTMC-b-PCL-OH polymers are formed, whereas introduction of TMC first or simultaneous addition of comonomers leads to hydroxyformatetelechelic HC(O)O-PTMC-b-PCL-OH analogues.

show abstract

Study of a (trimethylenecarbonate-co-ε-caprolactone) polymer—Part 1: preparation of a new nerve guide through controlled random copolymerization using rare earth catalysts

Cited by 96 publications

References 17 publications

Ring‐opening polymerization of trimethylenecarbonate and its copolymerization with ϵ‐caprolactone by lanthanide (II) aryloxide complexes

Ring‐opening polymerization of trimethylenecarbonate and its copolymerization with ϵ‐caprolactone by lanthanide (II) aryloxide complexes

Bioengineering of Articular Cartilage: Past, Present and Future

Unprecedented Polymerization of Trimethylene Carbonate Initiated by a Samarium Borohydride Complex: Mechanistic Insights and Copolymerization with ε‐Caprolactone

Contact Info

Product

Resources

About