Study of a myoglobin test in patients hospitalized for suspected myocardial infarction

Mainard, F; Massoubre, B; Marec, H le; Madec, Y

doi:10.1016/0009-8981(85)90132-9

Cited by 12 publications

(1 citation statement)

References 11 publications

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“…The differences could be attributed to the type of assays, that is, enzyme-linked immunosorbent assay (ELISA) vcrsus radioimmunoassay (RIA), immunoagglutination, nephelometric), the use of nionoclonal antibody versus polyclonal antibody or differences inherent in the populations studied. The average Mb peak in the AMI group exceeded those of the non-AM1 and control groups by a factor of [8][9], confirming previous reports (3,4,16), but appearing slightly higher than others (8,9,22,23). These differences could be due to computational factors, i.e., peak values versus the mean of consecutive samples, or the mean of abovenormal Mb levels, or, more likely, due to the type of AMI, extension of myocardial damage or its complications (24)(25)(26).…”

Section: Discussionsupporting

confidence: 89%

The levels of serum myoglobin in cardiac patients with elevated creatine kinase‐MB and suspected acute myocardial infarction

Moscoso

Kiefer

Shyamala

et al. 1993

Clinical Laboratory Analysis

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A monoclonal antibody enzyme immunoinhibition assay was used to quantitate serial serum myoglobin (Mb) levels in 121 patients who had > or = 5% creatine kinase-MB (CK-MB) and suspected acute myocardial infarction (AMI). Serum Mb levels higher than 0.16 micrograms/ml were considered abnormal. In 94% of these patients who were finally diagnosed with AMI, Mb levels were higher than 0.16 micrograms/ml, whereas all 30 normal control blood donors had lower Mb levels. Patients with anterior or inferior wall infarcts had higher Mb levels (> or = 0.64 micrograms/ml) than patients with lateral or subendocardial infarction. Only 68% (82/121) of patients evaluated by elevated CK-MB alone had a final diagnosis of AMI. In contrast, 94% (77/83) of patients who in addition showed elevated Mb had AMI. It is suggested that analysis of Mb levels allows a more accurate diagnosis of AMI in patients with elevated CK-MB than does reliance on CK-MB values alone.

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Section: Discussionsupporting

confidence: 89%

The levels of serum myoglobin in cardiac patients with elevated creatine kinase‐MB and suspected acute myocardial infarction

Moscoso

Kiefer

Shyamala

et al. 1993

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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Serum Myoglobin Levels in Patients With Ischemic Myocardial Insult

Isakov¹

1988

Arch Intern Med

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Quantitative automated latex nephelometric immunoassay for determination of myoglobin in human serum

Borque

Rus

Ruíz

1991

Clinical Laboratory Analysis

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We have evaluated a new latex nephelometric test for the quantitation of myoglobin in human serum. The assay consists of incubating the diluted serum sample (20-fold) for 12 min at room temperature with latex particles covalently coated with anti-myoglobin antibodies and then quantifying the change of light-scatter produced. The assay is fully automated on the Behring nephelometer analyzer with a sampling rate of 150 samples/hour. There is no interference from bilirubin (up to 340 mumol/l), haemoglobin (up to 7,000 mg/l), or rheumatoid factor (up to 1,100 int. units/ml). Myoglobin standard curve extends from 20 to 380 micrograms/l. Assay detection limit lies around 6 micrograms/l. Coefficient of variation ranged from 2.7 to 7.6%. Correlation coefficient between latex immunoassay and an RIA method was 0.987, calculated from the assay of 37 samples. A statistically significant difference was found between the distribution for females and males. The serum level of myoglobin showed an age-dependent variation. Concentrations up to 60 micrograms/l are considered to be normal.

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Study of a myoglobin test in patients hospitalized for suspected myocardial infarction

Cited by 12 publications

References 11 publications

The levels of serum myoglobin in cardiac patients with elevated creatine kinase‐MB and suspected acute myocardial infarction

The levels of serum myoglobin in cardiac patients with elevated creatine kinase‐MB and suspected acute myocardial infarction

Serum Myoglobin Levels in Patients With Ischemic Myocardial Insult

Quantitative automated latex nephelometric immunoassay for determination of myoglobin in human serum

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