Study of a “biological focal region” of high-intensity focused ultrasound

Wang, Zhibiao; Bai, Jing; Li, Faqi; Du, Yuchen; Wen, Shuang; Hu, Kai; Xu, Guihua; Ma, Pibo; Yin, Niangang; Chen, Wenzhi; Wu, Feng; Feng, Ruo

doi:10.1016/s0301-5629(02)00785-8

Cited by 74 publications

(48 citation statements)

References 17 publications

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“…It utilizes the physics characteristics of ultrasound beam with assemble and penetration, to focus low energy outside body on inner tumor target field, through instantaneous high temperature effect, cavitate effect, making tumor target tissue of focal zone coagulation necrosis, without destroying surrounding tissues [7][8][9][10][11][12][13][14] . HIFU has the following characteristics in therapy of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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AIM:To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment. RESULTS:After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95±44) U/L and AST (114±58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

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Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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“…but also on tissue features, structure and functional status. [17][18][19] Intraoperative MRI allows dynamic control of energy deposition using realtime MRI thermometry 1 ( Figure 2). Through MR thermometry, it is possible to monitor the temperature in the target volume in near real time and calculate the thermal dose received by the treated region.…”

Section: Mri-guided Focused Ultrasound Surgery Principles and Technomentioning

confidence: 99%

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Bazzocchi¹,

Napoli²,

Sacconi³

et al. 2016

BJR

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MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice. Both the imaging and therapeutic sides of the equipment are based on non-ionizing energy. This technique is a very promising option as potential treatment for several pathologies, including musculoskeletal (MSK) disorders. Apart from clinical applications, MRgFUS technology is the result of long, heavy and cumulative efforts exploring the effects of ultrasound on biological tissues and function, the generation of focused ultrasound and treatment monitoring by MRI. The aim of this article is to give an updated overview on a "new" interventional technique and on its applications for MSK and allied sciences

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“…Some HIFU dosimetry work has been done using empirical experimental data analysis on different tissues. For example, Wang et al [1] demonstrated, with in vitro and in vivo experiments on pig liver, that the HIFU lesion occurs at so-called "biological focal region" as a function of acoustic focal region (as measured in water), acoustic intensity, exposure time, irradiation depth within the tissue or overlaying tissues, tissue structure and its functional status. The effect of inhomogeneous overlaying tissues on the heating patterns and steady-state temperature distributions have been studied analytically using a random-phase screen model [2].…”

Section: Introductionmentioning

confidence: 99%

A Study of Effects of Tissue Inhomogeneity on HIFU Beam

Amin¹,

Roberts²,

Long³

et al. 2006

AIP Conference Proceedings

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The potential of high-intensity focused ultrasound (HIFU) will not be realized unless the effects of overlaying tissues are understood in such a way that allows for estimation of HIFU dose distribution at a target tissue. We employ computational models to examine the impact of phase aberration on tissue ablation. Thompson and Roberts have recently studied the effects of phase aberration on ultrasound focusing in aerospace engine materials such as titanium alloy, and have developed a computational model to examine these effects. The ultrasound beam observed after transmission through the fused quartz (homogeneous) and that observed after transmission through the titanium (inhomogeneous) demonstrate the severe beam wavefield amplitude distortion introduced by the velocity inhomogeneity-induced phase aberration. We study applicability of this approach to model phase aberration in inhomogeneous tissues and its effect on HIFU dose distribution around the focus. It is hypothesized that the ill-effects of phase aberration accumulate during propagation through intervening tissue in which field intensities are substantially lower than that in the focal zone, and it is therefore appropriate to use a linear acoustic model to describe the transport of energy from the transducer to the volume targeted for ablation. Abstract. The potential of high-intensity focused ultrasound (HIFU) will not be realized unless the effects of overlaying tissues are understood in such a way that allows for estimation of HIFU dose distribution at a target tissue. We employ computational models to examine the impact of phase aberration on tissue ablation. Thompson and Roberts have recently studied the effects of phase aberration on ultrasound focusing in aerospace engine materials such as titanium alloy, and have developed a computational model to examine these effects. The ultrasound beam observed after transmission through the fused quartz (homogeneous) and that observed after transmission through the titanium (inhomogeneous) demonstrate the severe beam wavefield amplitude distortion introduced by the velocity inhomogeneity-induced phase aberration. We study applicability of this approach to model phase aberration in inhomogeneous tissues and its effect on HIFU dose distribution around the focus. It is hypothesized that the ill-effects of phase aberration accumulate during propagation through intervening tissue in which field intensities are substantially lower than that in the focal zone, and it is therefore appropriate to use a linear acoustic model to describe the transport of energy from the transducer to the volume targeted for ablation. We present initial results of the simulation and experiments of beam measurements under water without and with different tissue layers.

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Study of a “biological focal region” of high-intensity focused ultrasound

Cited by 74 publications

References 17 publications

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

A Study of Effects of Tissue Inhomogeneity on HIFU Beam

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