Study Design of a Phase 2/3 Randomized Controlled Trial of Dupilumab in Adults with Bullous Pemphigoid: LIBERTY-BP ADEPT
Dédée F. Murrell,
Pascal Joly,
Victoria P. Werth
et al.
Abstract:Background: Bullous pemphigoid (BP) is a rare, autoimmune, blistering skin disease associated with high disease burden, profoundly decreased quality of life and increased morbidity. Emerging evidence supports an important role for type 2 inflammation in disease pathogenesis.Current management relies on topical and/or systemic corticosteroids, non-selective immunosuppressants and antibiotics with antiinflammatory properties, which are all limited by side effects and toxicities. Therefore, targeted, efficacious … Show more
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