Study Design and Outcomes of Korean Obstructive Lung Disease (KOLD) Cohort Study

Park, Tai Sun; Lee, Jae Seung; Seo, Joon Beom; Hong, Yoonki; Yoo, Jung‐Wan; Kang, Byung Ju; Lee, Sei Won; Oh, Yeon‐Mok; Lee, Sang‐Do

doi:10.4046/trd.2014.76.4.169

Cited by 48 publications

(54 citation statements)

References 27 publications

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“…From June 2005 to October 2010, 197 patients (174 COPD, 23 nonsmoker normal controls) were selected from the KOLD Cohort Study [20]. All patients underwent volumetric inspiration and expiration CT on the same CT scanner as well as a pulmonary function test (PFT).…”

Section: Study Populationmentioning

confidence: 99%

Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

et al. 2015

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Section: Study Populationmentioning

confidence: 99%

Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

et al. 2015

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“…Details of the KOLD Study have been published previously (21). Details of the KOLD Study have been published previously (21).…”

Section: Patientsmentioning

confidence: 99%

Association of Plasma Adipokines with Chronic Obstructive Pulmonary Disease Severity and Progression

Jeong

Woo

et al. 2015

Annals ATS

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Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression.Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes.Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years.Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV 1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratio were significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV 1 decline over the 3-year period.Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.

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“… 2 , 6 In the present study, we evaluated the annual lung function decline according to the GOLD guidelines, by using data from the Korean Obstructive Lung Disease (KOLD) cohort study, a multicenter prospective longitudinal study of patients with COPD in South Korea. 7 …”

Section: Introductionmentioning

confidence: 99%

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease

Kim¹,

Yoon²,

Oh³

et al. 2015

COPD

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BackgroundSince the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups A–D were introduced, the lung function changes according to group have been evaluated rarely.ObjectiveWe investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines.MethodsPatients with COPD included in the Korean Obstructive Lung Disease (KOLD) prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1), which was analyzed by random-slope and random-intercept mixed linear regression.ResultsA total 175 participants were included. No significant postbronchodilator FEV1 decline was observed between the groups (−34.4±7.9 [group A]; −26.2±9.4 [group B]; −22.7±16.0 [group C]; and −24.0±8.7 mL/year [group D]) (P=0.79). The group with less symptoms (−32.3±7.2 vs −25.0±6.5 mL/year) (P=0.44) and the low risk group (−31.0±6.1 vs −23.6±7.7 mL/year) (P=0.44) at baseline showed a more rapid decline in the postbronchodilator FEV1, but the trends were not statistically significant. However, GOLD stages classified by FEV1 were significantly related to the annual lung function decline.ConclusionThere was no significant difference in lung function decline rates according to the GOLD groups. Prior classification using postbronchodilator FEV1 predicts decline in lung function better than does the new classification.

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Study Design and Outcomes of Korean Obstructive Lung Disease (KOLD) Cohort Study

Cited by 48 publications

References 27 publications

Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

Association of Plasma Adipokines with Chronic Obstructive Pulmonary Disease Severity and Progression

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease

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