Study Comparing Midazolam and Nitrous Oxide in Dental Anxiety Control

Pereira-Santos, Darklilson; Brêda-Júnior, Marcus Antônio; Ferraz, Emanuela Prado; Crippa, Grasiele Edilaine; Oliveira, Fabíola Singaretti; Rocha-Barros, Valdemar Mallet da

doi:10.1097/scs.0b013e3182a15dfc

Cited by 22 publications

(30 citation statements)

References 13 publications

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“…Midazolam has become the standard drug because it is an ideal sedative for this type of surgical procedure. Its short action is consistent with the average duration of a dental procedure (5-7,13-18). However, contrary to most authors, Zanette et al (19) concluded in their work that diazepam would be better than midazolam in conscious sedation dentistry.…”

Section: Discussionsupporting

confidence: 73%

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Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction

Lp¹,

A²,

Almeida-Souza³

et al. 2016

Med Oral

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BackgroundAnxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction.Material and MethodsForty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).ResultsConsidering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.ConclusionsPassiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars. Key words:Passiflora incarnata, midazolam, anxiety, oral surgery.

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Section: Discussionsupporting

confidence: 73%

“…In addition, sedation with benzodiazepines requires that patients be accompanied to appointments with the recommendation not to operate motor vehicles or hazardous machinery for the duration of the drug’s pharmacological effects. Among the benzodiazepines, midazolam is most commonly used for sedation during dental treatments (5-7). …”

Section: Introductionmentioning

confidence: 99%

Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction

Lp¹,

A²,

Almeida-Souza³

et al. 2016

Med Oral

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“…The surgical procedures were performed in twenty-five healthy outpatients (52 % females) between 18 and 25 years of age using the split-mouth design. This kind of randomized clinical trial has been used in oral health research, comprising each of two treatments are randomly assigned to either the right or left halves of the patient, decreasing the bias of familiarity with the surgery (Pereira-Santos et al, 2013;Lesaffre et al, 2009). The attractiveness of this design is that it removes a lot of inter-individual variability from the estimates of the treatment effect (Lesaffre et al).…”

Section: Discussionmentioning

confidence: 99%

Effects of Oral Diazepam or Inhalatory Nitrous OxideOxygen for Conscious Sedation During Third Molar Surgery: A Randomized Controled Trial, Split Mouth Design

Cavalcanti

Cunha²,

Luz

2020

Int. J. Odontostomat.

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Anxiety in dental surgery may lead to behavioral and physiological changes for the patient and constitute a frequent challenge for the oral surgeon. The objective of this study was to compare the effect of inhalatory nitrous oxide and oxygen (N 2 O/O 2) with oral diazepam conscious sedation in vital signs of patients undergone third molar extraction. Outpatients who needed removal of partially impacted, bilateral lower third molars, during the period of one year, were included. Each patient underwent conscious sedation with either oral diazepam or inhalatory N 2 O/O 2 on a randomized controlled trial, split-mouth design. Systolic and diastolic blood pressure, heart rate and oxygen blood saturation were the changes measured before, at the beginning and the end of the procedure. Also, surgical procedure duration was recorded. Data from vital signs were submitted to analysis of variance and the duration of the surgery to paired Student's t-test. Twenty-five healthy outpatients (13 women and 12 men) with a mean age of 21.6 years were studied. There was an increase in systolic and diastolic pressure and in heart rate in the beginning; these values decreased and stabilized at the end of the surgical procedure in both treatments (p < 0.001) being lower in N 2 O/O 2 but without difference between treatments. The surgical procedure duration was lower and occurred an expected increase of oximetry under N 2 O/O 2 sedation (p < 0.001). Both treatments were effective for the conscious sedation but N 2 O/O 2 showed better outcomes, mainly in duration of the surgery.

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“…Corah’s Dental Anxiety Scale (DAS) [24], which is commonly used to assess dental anxiety [25–28], was administered as a third questionnaire to measure patient dental anxiety. The scale consists of 4 questions, each with 5 answer alternatives.…”

Section: Methodsmentioning

confidence: 99%

Effect of patient anxiety on image motion artefacts in CBCT

Keriş

2017

BMC Oral Health

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BackgroundArtefacts in images related to patient movement decrease image quality, potentially necessitating re-scanning, which leads to an extra radiation dose for the patient. Thus, avoiding patient motion reduces patient exposure to radiation. The aim of this study was to analyse image motion artefacts (MAs) and how they are affected by patient anxiety during cone beam computed tomography (CBCT) examination.MethodsA total of 100 patients undergoing CBCT examination were investigated. The State Trait Anxiety Inventory (STAI-S and STAI-T) form was used to measure patient anxiety. Patient’s age, gender, dental anxiety score, diagnostic reason for CBCT examination, field of view (FOV), acquisition time, anatomical area, and presence of motion artefacts on images were recorded. Comparisons of the parameters were evaluated using Pearson’s correlation, the chi-square test, the Mann-Whitney U test, the Kruskal-Wallis test and t-tests. The significance level was set at 0.05.ResultsThe mean values of the scores for the total population were 37.2 for the STAI-S and 41.6 for the STAI-T. Women exhibited higher anxiety levels than men. The patients’ anxiety scores were significantly correlated with dental fear. The prevalence of patients showing motion artefacts was 6%. The mean age of patients with motion artefacts on their images (56.83) was higher than that of patients without (39.14). There was no relationship between motion artefact presence and patient gender, anxiety score, diagnostic reason for CBCT examination, FOV, acquisition time, or anatomical area. Patients showing motion artefacts on their images had higher STAI scores than those with no motion artefacts (non-significant).ConclusionsThe population in this study experienced anxiety before CBCT scanning. Excessive anxiety did not clearly affect whether image motion artefacts were generated during CBCT examination, although a non-significant increase in STAI scores was noticed in patients with motion artefacts on their images.

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Study Comparing Midazolam and Nitrous Oxide in Dental Anxiety Control

Cited by 22 publications

References 13 publications

Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction

Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction

Effects of Oral Diazepam or Inhalatory Nitrous OxideOxygen for Conscious Sedation During Third Molar Surgery: A Randomized Controled Trial, Split Mouth Design

Effect of patient anxiety on image motion artefacts in CBCT

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