Study by Scanning Electron Microscopy of the Morphogenesis of Three Types of Lingual Papilla in the Mouse

Abstract

Tongues were removed from fetuses of mice on the 15th day of gestation (E15), from newborns (PO), from juveniles on the 7th day (P7) and on the 14th day (P14) after birth for examination by scanning electron microscopy. In the fetuses at E15, rudiments of fungiform papillae with a relatively regular, lattice-like pattern were visible on the anterior half of the dorsal surface of the tongue. The outline of the rudiment of a circumvallate papilla could be recognized on the median line between the lingual body and the lingual radix. No rudiments of filiform papillae could be seen. At PO, rudiments of filiform papillae were compactly distributed over the dorsal surface, as are the filiform papillae in the adult, their width was approximately one-third of that of fungiform papillae, and their tips were rounder than those of the filiform papillae in the adult. The fungiform papillae then increased in size and became somewhat irregular in shape. In juveniles at P7, the filiform papillae were long and slender, being relatively large on the intermolar eminence. A taste pore was visible in the center of each fungiform papilla at this stage. The shape of the circumvallate papilla was similar to that in the adult. In juveniles at P14, the shapes of all three types of papilla were almost the same as those in the adult. The rudiments of each of the three kinds of lingual papilla appeared at a different stage of development of mice; rudiments of the fungiform and circumvallate papillae, which are related to the sense of taste, were formed earlier than those of the filiform papillae, which are not involved in taste.

Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance

“…The development and micro-anatomy of lingual (i.e. tongue) papillae have been extensively studied, but their large-scale spatial organization has received little attention (Hume and Potten, 1976;Iwasaki et al, 1996). Both Fz3 and Fz6 are expressed in the tongue epithelium at E13.5, as judged by expression of the corresponding lacZ knock-in alleles (Fig.…”

Fine structure of the dorsal lingual epithelium in Tarentola annularis and Crocodylus niloticus

“…The most interesting features of the histological structures of reptilian tongues reflect adaptations to a dry habitat or to seawater, but stratification and keratinisation of the lingual epithelium are common features [19,20]. The alligator is an aquatic reptile and its lingual epithelium is strongly keratinised [19,45].…”

“…Tongue papillae are different in shape, size, number, nomenclature and distribution among different groups of vertebrates [7,20].…”

Light and Scanning Electron Microscopic Investigation of Postnatal Development of Vallate Papillae in the White Laboratory Mice

“…In the rats, vallate papilla has oval shape and is 1 mm in length and 0.5 mm in width (14). Vallate papilla takes its normal shape in mouse on the 13 th day (15,16) 13-13.5 th day (17) or 15 th day (18,21), in rats on the 16 th day (18) in prenatal days.…”

“…In the order of Rodentia, several prenatal (11,15) and postnatal (1,2,3,18,19) studies were carried out on vallate papillae.…”