Studio di valutazione del presidio Rigenoma con ozoile nel trattamento di lesioni cutanee croniche

Ricci, E; Pittarello, Monica; Giacinto, Francesco

doi:10.4081/ijwc.2022.90

Cited by 4 publications

(2 citation statements)

References 22 publications

(15 reference statements)

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“…As you can see from the image at the end of this section, the idea for a simple classification was based primarily on the severity and presentation of initial clinical findings and it was useful to quickly document the severity of the condition. 18 …”

Section: Methodsmentioning

confidence: 99%

Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation

Francavilla,

Secolo,

D'Armetta

et al. 2024

Eur J Transl Myol

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Ingrown toenails account for roughly 20% of all foot problems in primary care. It is most common in young men, with nail care habits and footwear being major contributors. Onychocryptosis is typically caused by self-treatment attempts to cure the condition in its early stages. Its clinical features are frequently confused with other osseous and soft tissue abnormalities. The goal of this study was to provide perspectives on the management of pain and inflammation in Onychocryptosis using an Ozoile-based hydrogel formulation in a semi-occlusive bandage for 14 days, while incorporating natural pharmacological solutions into established protocols. The primary outcomes measured were pain reduction on NRS and stadiation according to the Al Kline Classification. The reduction was statistically significant, with a mean decrease in VAS score from 10 to 4 (p < 0.05), and Al Kline classification decreased by an average of 1.6 stages. 42% of patients recovered within the first 15 days of treatment, and 93% by the end of the scheduled treatment.

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Section: Methodsmentioning

confidence: 99%

Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation

Francavilla,

Secolo,

D'Armetta

et al. 2024

Eur J Transl Myol

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“…Ozoile showed a decrease in LPS-induced inflammatory response in colonic epithelial cells and THP-1 monocytes [17]. Furthermore, in another study on patients with phlebostatic leg ulcers, Ozoile was shown to stimulate fibroblast proliferation and neoangiogenesis [18,19]. While the beneficial effects of Ozoile have been reported, in these studies no cytotoxic effects or sensitization with allergic reactions are described.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Alginate/Ozoile Gel Microspheres by Electrospray Process

Ciarleglio,

Russo,

Toto

et al. 2024

Gels

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Natural polymers, such as alginate and chitosan, are widely exploited for drug delivery applications due to their biocompatibility, low toxicity, and sustainable sourcing. In this study, pH-responsive gel microspheres were fabricated from an alginate/Ozoile emulsion. Ozoile (Stable Ozonides) is a biological inducer, derived from olive oil, which stimulates the endogenous defense system by promoting the repair of tissue damage and restoration of proper physiology through the regulation of gene transcription. Here, the versatile and cost-effective electrospray technique without the use of organic solvents was used to fabricate alginate/Ozoile microspheres with high throughput. The process parameters (voltage, flow rate, and needle gauge) were optimized to obtain microspheres with good sphericity factor and tailored diameter (250–700 μm). The microspheres were additionally optimized through a chitosan coating to enhance their stability and regulate the gel matrix’s degradation process. Morphological analysis, FTIR spectroscopy, and degradation tests confirmed the structural integrity and pH-responsive behavior of the gel microspheres. This research offers a promising route for targeted drug delivery systems, particularly in applications related to the modulation of oxidative stress and management of inflammation.

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The Effect of Topical Application With Ozoile® as a Novel Method in the Complex Treatment of Soft Tissue Infections and Chronic Wounds

Marinova

2023

TJS

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The treatment of severe and deep soft tissue infections, especially those combined with fascial necrosis is complex and involves a multidisciplinary team. The aim is to research the effect of topical application of Ozoile®, stable ozonides from organic extra-virgin olive oil +OILin the complex treatment of soft tissue infections and chronic wounds and to optimize the algorithm of these applications. Results: We applied LOT to a total of 84 patients (22.1%) of all 380 patients with soft tissue infections treated for the period March 2022-March 2023 at the First surgical clinic of Medical University – Pleven, Bulgaria. At Department “Surgical diseases” there were 49 (58,3%) patients with the superficial inflammatory process, 6 (7,1%) with chronic wounds, and 27 (34,6%) with deep soft tissue infection and necrotizing fasciitis who received topical applications of Ozoile®, stable ozonides from organic extra-virgin olive oil +OIL®OT. We compared the results with a group of 296 patients treated with conventional methods and routinely used antiseptics – hydroperoxide, povidone-iodine, and chlorhexidine gluconate. Statistically significant results in the Ozoile® group were: wound size reduction by 25% on the 5th day of treatment (p<0.04), reduction by 50% of baseline C-reactive protein levels on day 5th of treatment (p < 0.05), the local status of the wound on the 30th day after discharge - in the Ozoile® group we did not observe any complaints of redness, itching or other local discomforts (p< 0.05). We optimized an algorithm for the application of ozone therapy with OzoilE®

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Studio di valutazione del presidio Rigenoma con ozoile nel trattamento di lesioni cutanee croniche

Cited by 4 publications

References 22 publications

Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation

Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment and pain management using Ozoile as a hydrogel and cream formulation

Fabrication of Alginate/Ozoile Gel Microspheres by Electrospray Process

The Effect of Topical Application With Ozoile® as a Novel Method in the Complex Treatment of Soft Tissue Infections and Chronic Wounds

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