Studies with sub-toxic doses of α-chlorohydrin in the male monkey

Setty, B.S.; Kar, Amiya B.; Roy, Somnath; Chowdhury, S.R.

doi:10.1016/0010-7824(70)90047-8

Cited by 38 publications

(23 citation statements)

References 8 publications

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“…Similar results have been obtained with the rat (Samojlik and Chang 1970;. The observations that spermatozoa from Il(-chlorohydrin-treated monkeys apparently showed an increased oxygen uptake (Setty et al 1970) is, therefore, very puzzling.…”

Section: Discussionsupporting

confidence: 74%

Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

Pd¹,

White²

1976

Aust. Jnl. Of Bio. Sci.

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Section: Discussionsupporting

confidence: 74%

Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

Pd¹,

White²

1976

Aust. Jnl. Of Bio. Sci.

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“…Within the last few years, a number of papers were published on the post-testicular antifertility effect of l-chloro-2,3-propanediol (a-chlorohydrin) and some related compounds in male rats (Coppola, 1969;Gunn, Gould & Anderson, 1969;Jones, Davies, Edwards & Jackson, 1969;Samojlik & Chang, 1970;Turner, 1971). It has also been reported that a-chlorohydrin will inhibit fertility in male guinea-pigs and monkeys (Setty, Kar, Roy & Chowdhury, 1970;Kirton, Ericsson, Ray & Forbes, 1970). The precise mode of action of this compound is still obscure.…”

Section: Introductionmentioning

confidence: 95%

Oral Antifertility Effects of Halo Propanediol Derivatives in Male Rats

Banik¹,

Tanikella²,

Rakhit³

1972

Reproduction

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Ten derivatives of halo propanediol were tested orally for male antifertility effects in adult Sprague-Dawley rats. Six of these compounds were effective in inducing temporary sterility at a daily dose ranging from 2\m=.\5to 5 mg/rat. When administered over a minimum period of 7 days, these minimum effective doses did not interfere with the mating behaviour and spermatogenesis even during prolonged medication. However, at ten times the minimum effective dose, Compounds III (1-chloro-2,3-propanediol) and VII (1-chloro-2,3-bis[tetrahydropyran-2-yloxy]propane) caused severe testicular damage and irreversible sterility, while Compound X (4-[chloromethyl]-2-pentyl-1,3-dioxolane) did not. Our studies confirm that the presence of an \g=a\-chlorohydrin group is essential in halo propanediol derivatives for antifertility effects in male rats.

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“…Alphachlorohydrin (3-chloro-l,2-propanediol) induces reversible infertility in male rats, sheep, pigs hamsters and guinea-pigs when given in oral doses too low to produce toxic effects (Coppola, 1969;Ericsson & Youngdale, 1970;Ericsson & Baker, 1970;Johnson & Pursel, 1972;Brown & White, 1973;Lubicz-Nawrocki & Chang, 1974). However, in the rhesus monkey, doses of a-chlorohydrin which produce an antifertility effect are toxic (Kirton, Ericsson, Ray & Forbes, 1970;Setty, Kar, Roy & Chowdhury, 1970) and a-chlorohydrin itself has therefore been rejected as a potential contra¬ ceptive for humans. The a-chlorohydrin used in all these experiments was a racemic mixture and the individual enantiomers of a-chlorohydrin have not been generally available.…”

Section: Introductionmentioning

confidence: 96%

Effects of the optical isomers of -chlorohydrin on glycolysis by ram testicular spermatozoa and the fertility of male rats

Ford¹,

Harrison²,

Waites³

1977

Reproduction

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When 0-1 mM-S alpha-chlorohydrin was present in incubations, glycolysis by ram testicular spermatozoa was almost completely inhibited whereas 10 mM-R alpha-chlorohydrin had no effect. Male rats dosed orally with S alpha-chlorohydrin (3-25 mg/kg/day) became much less fertile than controls but those dosed with R alpha-chlorohydrin (13 mg/kg/day) did not. The loss of fertility was associated with a reduced ability of spermatozoa from the cauda epididymidis of these rats to oxidize glucose. It is concluded that the S enantiomer is responsible for both the inhibition of sperm glycolysis and the reduction in fertility caused by the racemic mixture of alpha-chlorohydrin.

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Studies with sub-toxic doses of α-chlorohydrin in the male monkey

Cited by 38 publications

References 8 publications

Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

Oral Antifertility Effects of Halo Propanediol Derivatives in Male Rats

Effects of the optical isomers of -chlorohydrin on glycolysis by ram testicular spermatozoa and the fertility of male rats

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