Studies towards C-3 functionalization of β-lactams using substituted allylsilanes

Abstract

An effective and stereoselective synthesis of 3-(1-methyl/phenylallyl)-3-phenylthio-β-lactams (3/4) using substituted allylsilane and Lewis acid is described. The reaction leads to the formation of a mixture of C-3 substituted allyl β-Lactams. However, these compounds on desulphurisation using tri-n-butyltinhydride and Raney Ni provide two separable diastereomers of the reduced product.

Synthesis, characterization, and antibacterial activity studies of β‐lactam capped silver nanoparticles

“…Our previous studies have proved the use of 3-phenylthio-β-lactams as an important synthons for C-3 functionalization reactions, thereby resulting in synthesis of a variety of novel β-lactams [24][25][26][27][28]. In continuation of such studies, we became interested in finding out the method to increase the utility of these compounds.…”