Studies on β-glucuronidase. 2. The preparation and properties of three ox-spleen β-glucuronidase fractions

Mills, George T.; Paul, John; Smith, Evelyn E. B.

doi:10.1042/bj0530232

Cited by 67 publications

(15 citation statements)

References 9 publications

(13 reference statements)

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“…These decreases were consistent with previous In vitro reports (Becker and Frledenwald, 1949;Mills et al, 1952;Fernley, 1962;Marsh, 1955) and with the report from an J_n vivo study of human urine (Young et al 1989). …”

Section: Discussionsupporting

confidence: 93%

Effect of ascorbic acid supplementation on beta‐glucuronidase activity in urine, intestinal, and cecal contents of rats

Nolan

Calabrese

Kenyon

1990

Journal of Environmental Science and Health . Part A: Environme

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Oral supplementation of ascorbic acid in adult male F344 rats that was equivalent to 2.5, 5.0, and 10.0 gram in humans based on W 2/3 was assessed for its capacity to inhibit beta-glucuronidase activity In urine and gastrointestinal contents. The ascorbic acid reduced the beta-glucuronidase activity in the cecal samples In all three groups in a range of from 24% to 38%. The high treatment group (i.e., the 5.0 gm human equivalent) for urinary values was associated with a decreased activity level of 25%.

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Section: Discussionsupporting

confidence: 93%

Effect of ascorbic acid supplementation on beta‐glucuronidase activity in urine, intestinal, and cecal contents of rats

Nolan

Calabrese

Kenyon

1990

Journal of Environmental Science and Health . Part A: Environme

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“…4). The inflexion in the pH curve at pH 4-5 is reminiscent of the multiple pH optima reported for ox spleen (Mills, Paul & Smith, 1953).…”

Section: Ribonuclea8ementioning

confidence: 68%

The biochemistry of epithelia. Hydrolytic enzymes of human bronchial epithelium

Spencer

1959

Biochemical Journal

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“…In the tissue of mammals, b-glucuronidase has been measured as a typical lysosomal enzyme through studies of subcellular fractionation. Pineda et al (2) demonstrated that liver damage caused an increase of the enzyme in blood, and liver cancer could be related to the enzyme (3), (4). We found that silymarin, a commercial crude drug used as a hepatoprotective, was found to inhibit b-glucuronidase in vitro as well as in vivo (5).…”

Section: Introductionmentioning

confidence: 77%

β-Glucuronidase Inhibitory Activity and Hepatoprotective Effect of 18β-Glycyrrhetinic Acid from the Rhizomes of Glycyrrhiza uralensis

Shim¹,

Kim²,

Kim³

2000

Planta med

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An inhibitor of beta-glucuronidase from the rhizomes of Glycyrrhiza uralensis was isolated and its hepatoprotective activity on CCI4-induced hepatotoxicity of rats was investigated. From the water-soluble extract of G. uralensis, glycyrrhizin was isolated as a potent inhibitor of beta-glucuronidase. When glycyrrhizin was orally administered, it had a hepatoprotective activity. However, when glycyrrhizin was intraperitoneally administered, it did not have a hepatoprotective activity. 18 beta-Glycyrrhetinic acid, which is a major metabolite of glycyrrhizin by human intestinal bacteria, was also a potent inhibitor of beta-glucuronidase. When 18 beta-glycyrrhetinic acid was intraperitoneally administered, it also had some hepatoprotective activity. These results suggest that glycyrrhizin may be a natural prodrug for the observed hepatoprotective effect in rats and that serum beta-glucuronidase levels have implications for the liver injury, as reductions of its activity by administration of inhibitors such as G. uralensis or its derived products and silymarin correlate with reductions in biochemical indices of liver injury.

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Studies on β-glucuronidase. 2. The preparation and properties of three ox-spleen β-glucuronidase fractions

Cited by 67 publications

References 9 publications

Effect of ascorbic acid supplementation on beta‐glucuronidase activity in urine, intestinal, and cecal contents of rats

Effect of ascorbic acid supplementation on beta‐glucuronidase activity in urine, intestinal, and cecal contents of rats

The biochemistry of epithelia. Hydrolytic enzymes of human bronchial epithelium

β-Glucuronidase Inhibitory Activity and Hepatoprotective Effect of 18β-Glycyrrhetinic Acid from the Rhizomes of Glycyrrhiza uralensis

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