Studies on uterine contractility following mifepristone and various routes of misoprostol

Sublingual misoprostol for first trimester termination of pregnancy

“…It was also found that uterine tonus increase is more rapid and more pronounced following sublingual administration compared with the vaginal route [14]. These results could explain the reduction in objective and subjective measurements of blood loss after sublingual misoprostol in the present study: the decrease not only in hematocrit but also in hemoglobin levels.…”

“…According to pharmacokinetic studies of the effect of misoprostol on uterine activity, uterine contraction following sublingual administration starts to decrease after 3 hours [12][13][14]. We chose a 4-hour interval between repeated sublingual misoprostol doses to minimize the adverse effects because its action is unlikely to continue beyond this time.…”

Mifepristone and Misoprostol for the management of placenta accreta – a new alternative approach

“…In combination with Misoprostol, Mifepristone has been used successfully over the last decade in termination of pregnancy in every trimester. Misoprostol is a prostaglandin E 1 analogue causing increased uterine tonus thus helping expulsion of the placenta 4 . Mifepristone as a pre‐treatment to Misoprostol results in shorter induction to delivery interval with 95% success within 24 hour 5 .…”

“…Misoprostol is a prostaglandin E 1 analogue causing increased uterine tonus thus helping expulsion of the placenta. 4 Mifepristone as a pre-treatment to Misoprostol results in shorter induc-tion to delivery interval with 95% success within 24 hour. 5 Maximum effect of this regimen is achieved when Misoprostol is administered 36-48 hour after Mifepristone.…”

Update on Medication Abortion

“…Misoprostol may be either taken by mouth or administered per vagina, and in the case of uncomplicated but incomplete abortion, the dose may be repeated, although data are inconsistent on the additional efficacy of a second dose 18–20 . Gestational age limits have expanded from 49 to 63 days while preserving a high rate of efficacy when the 800 μg dose of misoprostol is used vaginally.…”