Studies on Tsutsugamushi Disease (Scrub Typhus, Mite-Borne Typhus) in New Guinea and Adjacent Islands:

Blake, Francis G.; Maxcy, Kenneth F.; Sadusk, Joseph F.; Kohls, Glen M.; Bell, E. John

doi:10.1093/oxfordjournals.aje.a119018

Cited by 36 publications

(21 citation statements)

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“…There were several outbreaks among Allied troops near Port Moresby and beyond [11,[221][222][223]. The highly virulent O. tsutsugamushi prototype Karp strain was isolated from the blood of a febrile soldier who had been deployed there [40,41].…”

Section: Geographic Distribution Of Antigenic Typesmentioning

confidence: 99%

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

et al. 2009

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Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region. Historically, strain characterization used serological analysis and revealed dramatic antigenic diversity. Eyeing a recommendation of potential vaccine candidates for broad protection, we review geographic diversity and serological and DNA prevalences. DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity. According to serological analysis, approximately 50% of isolates are seroreactive to Karp antisera, and approximately one-quarter of isolates are seroreactive to antisera against the prototype Gilliam strain. Molecular methods reveal greater diversity. By molecular methods, strains phylogenetically similar to Karp make up approximately 40% of all genotyped isolates, followed by the JG genotype group (Japan strains serotypically similar to the Gilliam strain but genetically non-Gilliam; 18% of all genotyped isolates). Three other genotype groups (Kato-related, Kawasaki-like, and TA763-like) each represent approximately 10% of genotyped isolates. Strains genetically similar to the Gilliam strain make up only 5% of isolates. Strains from these groups should be included in any potential vaccine.

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Section: Geographic Distribution Of Antigenic Typesmentioning

confidence: 99%

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

et al. 2009

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“…As was mentioned before, the resistance of animals infected subcutaneously with Rickettsia orientalis to reinfection of the same agent was proved to be common among many strains of this agent, and this immunological response was used for a final identification of the agent by many workers (Smadel et al, 1944;Blake et al ., 1945; AGAINST SCRUB TYPHUS RICKETTSIA, II 401 Kawamura et al, 1953;Jackson e t al., 1957). In the previous paper (Shishido et al, 1958) the resistance of mice after subcutaneous infection of Kato strain, a reference strain of Rickettsia orientalis in Japan, was analysed and satisfactory results were obtained in protection tests.…”

Section: Discussionmentioning

confidence: 96%

The Nature of Immunity Against Scrub Typhus in Mice Ii. The Cross-Protection Test With Mice for Identification and Differentiation of Several Strains of Rickettsia Orientalis Newly Isolated in Japan

Shishido¹,

Ohtawara²,

Hikita³

et al. 1959

JJMSB

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“…T h e Kostival strain was recovered in November, 1943, from a patient in the Dobadura area of New Guinea by Blake and his coworkers (6). I t also has been employed in earlier studies of scrub typhus vaccine in this laboratory (17).…”

Section: ~0mentioning

confidence: 99%

“…Blood from a mouse of the sixth passage was injected into embryonated eggs (6) and yolk sac material from the 6th to 24th subcultures of this line was employed in the current work. The wild rat 235 strain (also referred to as wild rat 2 (14)), was obtained during April, 1944, by Kohls and his coworkers (7) from the pooled brains of four wild rats (Rattu, s cw~olor brown/) which were trapped in the Dobadura area of New Guinea.…”

Section: ~0mentioning

confidence: 99%

Studies on Scrub Typhus (Tsutsugamushi Disease)

Rights

Smadel

1948

Journal of Experimental Medicine

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Although animals which recover from disease induced by one strain of Rickettsia tsutsugamushi are resistant to infection with heterologous strains (1-10), all organisms now grouped in this subgenus are not antigenically homogeneous. Evidence for heterogeneity is obtained in serological studies which employ complement fixation (11, 12), serum protection (13), and toxin-antitoxin techniques (14). Non-infectious vaccines of several types are capable of immunizing mice against the homologous strain of R. tsutsugamushi (15)(16)(17) but the degree of protection elicited by such materials against heterologous strains is unknown. The present report supplies information on this point and provides additional evidence of antigenic differences among the members of the scrub typhus group of agents. Materials and MethodsStrains ofR. tsutsugamushi.--The eight strains of R. tsutsugamushi employed in the current investigation were selected to represent the agent as obtained from various geographical areas and from different zoological sources; i.e., men, mites, and rats. The origin and lineal descent of these strains are given in some detail in the following paragraphs since it appears desirable to establish these points clearly. Certain of the immunological and serological data which indicate the known relationships of the eight to each other, or to additional strains of R.

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Studies on Tsutsugamushi Disease (Scrub Typhus, Mite-Borne Typhus) in New Guinea and Adjacent Islands:

Cited by 36 publications

References 0 publications

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

The Nature of Immunity Against Scrub Typhus in Mice Ii. The Cross-Protection Test With Mice for Identification and Differentiation of Several Strains of Rickettsia Orientalis Newly Isolated in Japan

Studies on Scrub Typhus (Tsutsugamushi Disease)

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