Studies on Trypanosome-resistant cattle. II. The effect of Trypanosomiasis on N'dama, Muturu and Zebu cattle

Roberts, C. J.; Gray, A. R.

doi:10.1007/bf02240423

Cited by 79 publications

(35 citation statements)

References 13 publications

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“…There are however sufficient evidence and examples for a number of African breeds that have unique characteristics with regard to adaptations to heat and disease susceptibility (Bonsma, 1980). Cattle breeds such as the Ndama has resistance against tryponosomasis (Roberts & Gray, 1973;Mattioli et al 2000) and Sanga breeds such as the Nguni of South Africa has been shown to be more adapted to subtropical areas with high temperature, humidity and feeding requirements and tick resistance (Spickett et al 1989;Mapiye et al 2007). Research as indicated that sheep breeds such as the Red Maasai has a higher resistance against endoparasites compared to Dorper sheep (Barker, 1998), while West African Djallanke sheep showed resistance against tryponosomasis and endoparasite infections (Goosens, 1999).…”

Section: Livestock Breeds In Africamentioning

confidence: 99%

A Perspective on the Impact of Reproductive Technologies on Food Production in Africa

Marle-Köster

Webb

2013

Current and Future Reproductive Technologies and World Food Production

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Africa for the largest part is still regarded as part of the developing world and has a history of political instability, natural disasters, floods and droughts that all had an effect on the development of livestock production systems and the potential application of biotechnologies. It is expected that the human population in sub Saharan Africa will experience a growth of 1.2 % per year over the next 30 years. There is therefore pressure to increase sustainable productivity of livestock. Reproductive technologies such as Artificial Insemination in Africa were driven primarily by the need to control or prevent venereal diseases like Trichomoniases and Campylobacter fetus venerealis in cattle. Reproductive biotechnology had a limited impact in Africa due to several factors including a lack of infrastructure and animal recording systems, clear breeding objectives and continuously changing production systems and markets. Africa has a large variety of genetic resources adapted to the diverse environment and production systems and biotechnology should be applied within this context for an increase in food production.

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Section: Livestock Breeds In Africamentioning

confidence: 99%

A Perspective on the Impact of Reproductive Technologies on Food Production in Africa

Marle-Köster

Webb

2013

Current and Future Reproductive Technologies and World Food Production

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“…Animal trypanotolerance is the genetic ability of some breeds from several mammalian species (such as cattle, small ruminants, pigs, wild buffaloes and antelopes...) to live normally and remain productive in tsetse-infested areas [12]. This phenomenon was described in Africa as early as the beginning of the XXth century [4,6,7,29,33,35]. Trypanotolerance results from various biological mechanisms under multigenic control, which relate either to the control of trypanosome infection, as measured by parasitemia [10,13,22,34], or the control of the pathogenic effects of the parasites, the most prominent of which is anaemia [1,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Serial analysis of gene expression (SAGE) in bovine trypanotolerance: preliminary results

Berthier

Quéré²,

Thévenon

et al. 2003

Genet. Sel. Evol.

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-In Africa, trypanosomosis is a tsetse-transmitted disease which represents the most important constraint to livestock production. Several indigenous West African taurine (Bos taurus) breeds, such as the Longhorn (N'Dama) cattle are well known to control trypanosome infections. This genetic ability named "trypanotolerance" results from various biological mechanisms under multigenic control. The methodologies used so far have not succeeded in identifying the complete pool of genes involved in trypanotolerance. New post genomic biotechnologies such as transcriptome analyses are efficient in characterising the pool of genes involved in the expression of specific biological functions. We used the serial analysis of gene expression (SAGE) technique to construct, from Peripheral Blood Mononuclear Cells of an N'Dama cow, 2 total mRNA transcript libraries, at day 0 of a Trypanosoma congolense experimental infection and at day 10 post-infection, corresponding to the peak of parasitaemia. Bioinformatic comparisons in the bovine genomic databases allowed the identification of 187 up-and downregulated genes, EST and unknown functional genes. Identification of the genes involved in trypanotolerance will allow to set up specific microarray sets for further metabolic and pharmacological studies and to design field marker-assisted selection by introgression programmes. SAGE / trypanotolerance / N'Dama / Trypanosoma congolense / transcriptomics

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“…This ability to withstand trypanosome infection, called trypanotolerance, is an innate feature of the Longhom NÕDama and other Shorthorn cattle from West Africa (Roberts and Gray 1973;Roelants 1986;Doko et al 1991). At the International Livestock Research Institute (ILRI) in Nairobi, Kenya, a linkage study was initiated on an F 2 generation of a cross between NÕDama and Boran cattle to identify genes or QTL involved in trypanotolerance (Teale 1993).…”

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confidence: 99%

Marker-assisted introgression of Trypanotolerance QTL in mice

2005

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A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of the donor QTL alleles through the backcross (BC) phase. At the fourth BC generation, single-carrier animals were selected for the production of homozygous animal in the intercross phase. The QTL regions (QTLR) were located on chromosomes MMU1, MMU5, and MMU17. Groups of mice with different genotypes and the parental lines were subjected to a challenge with Trypanosoma congolense. The results show that trypanotolerance QTL was successfully moved into the recipient background genotype, yielding a longer survival time. The mean estimated survival time was 57.9, 49.5, and 46.8 days for groups of mice carrying the donor QTL on MMU1, MMU5, and MMU17 on A/J background. The mean estimated survival time was 29.7 days for the susceptible A/J line and 68.8 days for the resistant C57BL/6 line. The estimated QTLR effects are close to 30% smaller than those in the original mapping population which was likely caused by the difference in the background on which the effects of QTLR are tested. This is the first report of successful marker-assisted introgression of QTL in animals. It is experimental proof of the use of genetic markers for marker-assisted introgression in animal breeding.

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Studies on Trypanosome-resistant cattle. II. The effect of Trypanosomiasis on N'dama, Muturu and Zebu cattle

Cited by 79 publications

References 13 publications

A Perspective on the Impact of Reproductive Technologies on Food Production in Africa

A Perspective on the Impact of Reproductive Technologies on Food Production in Africa

Serial analysis of gene expression (SAGE) in bovine trypanotolerance: preliminary results

Marker-assisted introgression of Trypanotolerance QTL in mice

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