Abstract:SummaryAlterations in the levels of copper, zinc, and cadmium were investigated in both serum and buccal mucosa of hamsters in progressive pathology, namely, hyperplasia, papilloma, early invasive carcinoma, and well-differentiated squamous cell carcinoma. Hamster buccal pouch carcinogenesis was induced by tri-weekly topical application of a 0.5% solution of 7,12-dimethylbenz(a)anthracene (DMBA) in liquid paraffin applied with a brush on the right buccal mucosa for 16 weeks. Serum copper levels and the copper/… Show more
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