Studies on thrombopoiesis

Schulman, Irving; Abildgaard, Charles F.; Cornet, Joann; Simone, Joseph V.; Currimbhoy, Z

doi:10.1016/s0022-3476(65)80124-x

Cited by 30 publications

(6 citation statements)

References 14 publications

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“…However, these and other studies (56,(74)(75)(76)(77), particu larly that of Kelemen and co-workers (78), suggest that circulating regulators of platelets may indeed be demonstrable. Kelemen and co-workers harvested serum from mice before and at various times after splenectomy, gamma and ultraviolet irradiation, hemorrhage, and induced intravascular coagulation.…”

Section: Plateletsmentioning

confidence: 70%

Homeostatic Regulatory Mechanisms of Hematopoiesis

Boggs¹

1966

Annu. Rev. Physiol.

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Section: Plateletsmentioning

confidence: 70%

Homeostatic Regulatory Mechanisms of Hematopoiesis

Boggs¹

1966

Annu. Rev. Physiol.

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“…Despite the fascination for TTP and ADAMTS13 during the last decade (44), and the fact that since the first descriptions of hereditary TTP by Schulman et al (8) and Upshaw (9), respectively, we have made quite some progress, the situation for hereditary TTP patients is still often unsatisfactory. Knowledge on and awareness of this rare disease will increase through mutual efforts, including the hereditary TTP registry and hopefully give the development of a home-treatment a new momentum.…”

Section: Resultsmentioning

confidence: 99%

“…The first case of hereditary TTP was reported by Irving Schulman and coworkers in 1960 (8). They studied a girl of German origin over a period of several years.…”

Section: Historical Aspectsmentioning

confidence: 99%

“…A number of patients have had (severe) hyper bilirubinaemia, once in a while necessitating exchange transfusions during the neonatal period. In addition, episodes of thrombocytopenia are frequent, and many patients have been misdiagnosed with immune thrombocytopenic purpura (ITP) or Evans' syndrome leading to futile treatment with corticosteroids or even splen ectomy, as seen in Schulman's case (8).…”

Section: Organ Involvementmentioning

confidence: 99%

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Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry

Taleghani¹,

Krogh²,

Fujimura³

et al. 2013

Hamostaseologie

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SummaryHereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome, is a rare recessively inherited disease. Underlying is a severe constitutional deficiency of the von Willebrand factor-cleaving protease, ADAMTS13, due to compound heterozygous or homozygous mutations in the ADAMTS13 gene. The clinical picture is variable and more and more patients with an adult-onset are diagnosed.In the majority of countries the only available treatment is plasma, which when administered regularly can efficiently prevent acute disease bouts. The decision to initiate regular prophylaxis is often not easy, as evidence based guidelines and long term outcome data are lacking. Through the hereditary TTP registry (www.ttpregistry.net, ClinicalTrials.gov identifier: NCT01257269), which was initiated in 2006 and is open to all patients diagnosed with Upshaw-Schulman syndrome and their family members, we aim to gain further information and insights into this rare disease, which eventually will help to improve clinical management of affected patients.

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“…Hitherto attempts to demonstrate the presence of the hormone in plasma have rested on finding a raised platelet count in recipient animals, the increases being relatively small, of the order of 20 to 25 y,N over the resting platelet count (Kelemen et al, 1958;Linman et al, 1959;Rak et al, 1959;Odell et al, 1961;Spector, 1961;Schulman et al, 1965;McClure and Choi, 1968). Errors inherent in all visual methods of counting platelets are considerable even under the most carefully controlled conditions (Hellem, 1960), and in many of the studies referred to above the technique used for counting platelets is not quoted; the possibility of observer bias in visual counting methods is always present unless specific precautions are taken to avoid this.…”

Section: Brmtish Discussionmentioning

confidence: 99%

Isotope Bioassay for "Thrombopoietin"

Penington¹

1970

BMJ

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An assay system has been developed in mice for the humoral agent "thrombopoietin." This is based on utilization in newly-formed platelets of the radio-amino-acid (75)Se selenomethionine 24 hours after intravenous injection. The possibility that the results could be due to the effects of species antibody, to foreign protein, or to an effect primarily on selenomethionine metabolism, has been explored, but the findings are consistent with the presence of a physiological humoral factor. Thrombopoietin has been shown to be present in the plasma of patients suffering from severe thrombocytopenia of varied aetiology.

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Studies on thrombopoiesis

Cited by 30 publications

References 14 publications

Homeostatic Regulatory Mechanisms of Hematopoiesis

Homeostatic Regulatory Mechanisms of Hematopoiesis

Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry

Isotope Bioassay for "Thrombopoietin"

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