Studies on thermal, spectral, magnetic and biological properties of new Ni(II), Cu(II) and Zn(II) complexes with a bismacrocyclic ligand bearing an aromatic linker

Bucur, Cristina; Badea, Mihaela; Chifiriuc, Mariana Carmen; Bleoţu, Coralia; Iorgulescu, Emilia Elena; Badea, Irinel Adriana; Grecu, Maria Nicoleta; Lazăr, Veronica; Patriciu, Oana‐Irina; Marinescu, Dana; Olar, Rodica

doi:10.1007/s10973-013-3460-1

Cited by 4 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, compounds of type [M 2 (bmc3)Cl 4 ]·nH 2 O ( 56 ) (M: Ni, Cu, Zn; bmc3: 1,4-bis( N , N -1,3,6,9,12-pentaazacyclotridecane)-benzene) exhibited good anti-biofilm activity, especially against S. aureus and E. coli strains, the most active being the copper(II) complex. In addition, all complexes disrupt the membrane integrity of human ileocecal adenocarcinoma (HCT 8) tumour cells [ 131 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

Self Cite

View full text Add to dashboard Cite

Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

show abstract

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%