Studies on the Vasculature of the Corpus of the Human Uterus

Lundgren, Nils

doi:10.3109/00016345709155391

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…The uterine blood flow, including the maternal placental blood flow during pregnancy, is influenced not only by alterations in the uterine vasculature, but also by the contractile activity of the surrounding myometrium. Thus, visceral and vascular uterine smooth muscles are closely related structures, and form direct connections through myometrial fibers attached to the arterial tunica media (100). A decrease in uterine blood flow correlating to both intensity and frequency of uterine contractions has been found in animal models (73), and has also been demonstrated by angiography during human labour (18).…”

Section: Smooth Muscle Tissues Involved In Regulation Of Uteroplacentmentioning

confidence: 97%

Contraction and Relaxation of Human Uterine and Placental Smooth Muscle

Maigaard

1987

Acta Obstet Gynecol Scand

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Section: Smooth Muscle Tissues Involved In Regulation Of Uteroplacentmentioning

confidence: 97%

Contraction and Relaxation of Human Uterine and Placental Smooth Muscle

Maigaard

1987

Acta Obstet Gynecol Scand

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“…This feature was not seen in the uteroplacental arteries in normal pregnancies. There is general agreement on the anatomy of the blood to the human non-pregnant uterus (Dakaard 1946;Lundgren 1957 arcuate arteries derive from the uterine arteries and run in the outer third of the myometrium, giving off two sets of vessels, the centrifugal ones which nourish the outer one-third of the myometrium and the centripetal ones which branch in a fan-like manner towards the endometrium. These centripetally directed arteries are the radial arteries and they give 'off basal branches that supply only the basal endometrium and then break up into terminal spiral arteries.…”

Section: Luminal Endovascular Trophoblastmentioning

confidence: 99%

“…Haernatoxylin and eosin X 68.There is general agreement on the anatomy of the blood to the human non-pregnant uterus(Dakaard 1946;Lundgren 1957;Harris & Ramsey 1966;Boyd & Hamilton 1970). Haernatoxylin and eosin X 68.There is general agreement on the anatomy of the blood to the human non-pregnant uterus(Dakaard 1946;Lundgren 1957;Harris & Ramsey 1966;Boyd & Hamilton 1970).…”

mentioning

confidence: 96%

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

Khong¹,

Wolf²,

Robertson³

et al. 1986

BJOG

1,523

680

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An examination of the maternal vascular response to placentation shows that physiological changes in the placental bed normally extend from the decidua into the inner myometrium. In pre-eclampsia and in a proportion of pregnancies with small-for-gestational age infants (SGA) the physiological changes are restricted to the decidual segments alone. In addition, complete absence of physiological changes throughout the entire length of some spiral arteries is seen in pre-eclampsia and SGA. This new observation is confirmed in a study of basal plates of placentas from abnormal pregnancies. Intraluminal endovascular trophoblast may be seen in the placental bed spiral arteries in the third trimester in pre-eclampsia and SGA, a feature not seen beyond the second trimester in normal pregnancy. These findings point to a defect in the normal interaction between migratory trophoblast and maternal uterine tissues in pre-eclampsia and in SGA.

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“…The maternal placental vascular resistance is mainly determined by the diameter of the myometrial vessels, which is affected not only by the tone of the smooth muscle of the vascular wall, but also by the surrounding myometrial smooth muscle tissues. These influence the Correspondence : S. Maigaard, MD, Department of Obstetrics and Gynecology, Aarhus Kommunehospital, DK-8000 Aarhus C, Denmark. vessels by compression, and possibly also by distortion through thin fibrils connecting the tunica media of the arteries with the muscle fibres of the myometrium (Lundgren 1957).…”

mentioning

confidence: 99%

Differential effects of angiotensin, vasopressin and oxytocin on various smooth muscle tissues within the human uteroplacental unit

Maigaard

Forman

Andersson

1986

Acta Physiologica Scandinavica

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Tissue specimens from various parts of the uteroplacental unit were obtained from women undergoing caesarean section, and placental tissue from women with normal deliveries. Strips of myometrial tissue, and segments of intramyometrial arteries were dissected together with segments of chorionic plate arteries and veins, and stem villous arteries. The preparations were mounted in organ baths, isometric tension recorded, and the responses to angiotensin II, vasopressin, and oxytocin were studied. In myometrial preparations, angiotensin caused a slight, transient increase in the frequency of spontaneous contractions, but no changes in amplitude. In all vascular preparations angiotensin produced concentration-related contractions. The responsiveness of the preparations was myometrial artery greater than villous artery greater than chorionic plate artery = chorionic plate vein. All responses were transient and tachyphylaxis was pronounced in all tissues. Tachyphylaxis was not influenced by pretreatment with indomethacin. Vasopressin increased transiently frequency and amplitude of contractions in myometrial strips. Myometrial arteries responded with a sustained contraction, as did chorionic plate arteries and veins but the latter vessels were less responsive. Villous arteries did not respond to vasopressin. Oxytocin preferentially stimulated myometrial strips, but also had a weak concentration-related contractant effect on chorionic plate arteries and veins. Villous arteries did not respond to oxytocin. At a higher concentration, causing a pronounced increase in the frequency and amplitude of contractions of myometrial strips, oxytocin abruptly caused a marked contraction of myometrial arteries. Lower concentrations of the peptide had almost no effects. The results suggest that various smooth muscle tissues of the human uterus and placenta are highly differentiated as regards responses to angiotensin II, vasopressin, and oxytocin. The physiological and possible clinical importance of the present findings deserve further investigation.

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Studies on the Vasculature of the Corpus of the Human Uterus

Cited by 5 publications

References 64 publications

Contraction and Relaxation of Human Uterine and Placental Smooth Muscle

Contraction and Relaxation of Human Uterine and Placental Smooth Muscle

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

Differential effects of angiotensin, vasopressin and oxytocin on various smooth muscle tissues within the human uteroplacental unit

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