Studies on the tumor‐promoting activity of biomaterials: Inhibition of metabolic cooperation by polyetherurethane and silicone

Tsuchiya, Toshie; Hata, Hideyo; Nakamura, Akitada

doi:10.1002/jbm.820290116

Cited by 26 publications

(21 citation statements)

References 9 publications

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“…Tsuchiya et al reported that the tumorigenic potentials of these PEUs were correlated with their inhibitory potentials on GJIC using V79 metabolic cooperation assay, and hypothesized that cell-material interaction may play a major role in tumor promotion. 3,4 However, it is probable that not only GJIC but other factors may play a role in tumor formation, especially in tumor initiation, induced by implantation of tumorigenic materials. It has been known from the observation by Brand et al that preneoplastic cells already exist in a foreign bodyreactive tissue within 4-8 weeks postimplantation, although the role of the implant on the initiation stage is still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Studies on the mechanisms of tumorigenesis induced by polyetherurethane in rats: Production of superoxide, tumor necrosis factor, and interleukin 1 from macrophages cultured on different polyetherurethanes

Nakaoka

Tsuchiya

Nakamura

2000

J. Biomed. Mater. Res.

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Interaction of macrophages (Mos) with polyetherurethane (PEU) was investigated to clarify the role of the Mos in the early stage of tumorigenesis of PEUs. As for the inflammatory cytokines produced from Mos, the amount of tumor necrosis factor (TNF) produced on three PEUs (PU-4, 6, and 8) was similar, but less than that on a control glass dish. Interleukin 1 (IL-1) production levels on the PEUs, especially on PU-6, also decreased in comparison with the glass dish. Superoxide (O(2)(-)) release from Mos on the PEUs was similar or more than that on the glass dishes within 24 h incubation. In particular, the O(2)(-) release on PU-6, possessing the lowest tumorigenic potential in vivo, reached the highest level among the PEUs tested. To clarify the causes that enhanced O(2)(-) release from Mos, the methanol extracts of the three PEUs and chemicals that constitute the PEUs were tested. The extracts and 1,4-butanediol did not show an effect on O(2)(-) release. However, 4, 4'-di(ethoxycarboamide) diphenylmethane, a model hard segment of PEU, was remarkably enhanced, whereas poly(tetramethyleneoxide), a soft segment of PEU, reduced the O(2)(-) release in a dose-dependent manner. From these results, although it is still unclear what affects different types of O(2)(-) production, lower tumorigenic potentials of PU-6 may be caused by O(2)(-) release from Mos, which play an important role in the tumoricidal process. Further, the low IL-1 production on PU-6 suggests that PU-6 suppresses inflammatory responses other than O(2)(-) production in vivo, resulting in lower tumorigenic potentials. On the other hand, TNF production was almost similar when Mos were cultured on three PEUs, suggesting TNF did not play a role in the different tumorigenic potentials of PEUs.

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Section: Discussionmentioning

confidence: 99%

“…4 Five grams of each PEU dissolved in 20 mL of THF was dropped into 200 mL of methanol to precipitate the PEU, and left for 3 days. After filtration of the mixture, the precipitate was left in another 200 mL of methanol for a further 3 days, followed by filtration.…”

Section: Extraction Of Leachable Substance From Peumentioning

confidence: 99%

Studies on the mechanisms of tumorigenesis induced by polyetherurethane in rats: Production of superoxide, tumor necrosis factor, and interleukin 1 from macrophages cultured on different polyetherurethanes

Nakaoka

Tsuchiya

Nakamura

2000

J. Biomed. Mater. Res.

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“…10,11 In addition, GJIC plays an essential role in homeostasis maintenance by keeping many growth control signals at equilibrium among GJIC-connected cells and tissues. 13 Therefore, it is important to clarify the inhibitory activity of the materials on GJIC to estimate both their biocompatibility and their undesirable effects in vivo.…”

Section: Discussionmentioning

confidence: 99%

Neural differentiation of midbrain cells on various protein‐immobilized polyethylene films

Nakaoka

Tsuchiya

Nakamura

2003

J Biomedical Materials Res

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The effect of surface modification of polyethylene (PE) film on differentiation of midbrain (MB) cells obtained from rat embryos was determined by their micromass culture system. When cultured on untreated PE film, cell differentiation was suppressed to approximately two-thirds of that observed in a control culture dish. On the contrary, type I collagen-immobilized PE film increased differentiated foci of the MB cells more than did the untreated PE film. RGDS (Arg-Gly-Asp-Ser) peptide immobilization onto PE film resulted in almost the same differentiation activity as the collagen immobilized PE film. Bovine serum albumin (BSA) immobilization onto PE film enhance the differentiation activity more than did the untreated PE film, but not up to the levels of collagen- and RGDS-immobilized PE. The number of differentiated foci of the MB cells on untreated PE film were increased by the addition of the condition medium prepared from the collagen-immobilized PE film. However, the number of foci was not increased by the addition of other condition media obtained from control dish, untreated, BSA-, and RGDS-immobilized PE. On the other hand, none of these condition media enhanced a differentiation of the neuronal cell line of PC12 cells, suggesting that some factors effectively differentiate midbrain cells, composed of neuronal epithelial and mesenchymal cells, but not the PC12 cells secreted in the condition media prepared from collagen-immobilized PE. In addition, it is probable that neural growth factor was not secreted in these condition media, which could not induce the differentiation of PC12 cells.

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“…With both degradable and nondegradable materials, this can induce chronic inflammatory reactions which may result in implant failures 1 and even in tumor-promoting activity. 2,3 Recent studies have shown that tissue reactions which are important for the biocompatibility of biomaterials mainly concern (varieties of) a (sterile) inflammatory reaction. Cellular and humoral factors, such as platelets, granulocytes, macrophages, lymphocytes, fibroblasts, giant cells, 4 adhesion molecules, 5 the coagulation cascade (e.g., bradykinin), 6 complement, 7,8 and cytokines [9][10][11] can be involved in the mentioned unwanted tissue reaction.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the tissue reaction to biomaterials. II. The function of T cells in the inflammatory reaction to crosslinked collagen implanted in T-cell-deficient rats

Luyn

Khouw

Wachem

et al. 1998

J. Biomed. Mater. Res.

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Unwanted tissue reactions are often observed resulting in events such as early resorption of the biomaterial, loosening of the implant, or a chronic (immunologic) response. From immunologic studies it is known that inflammatory reactions can be modulated by use of (anti)-growth factors or anti-inflammatory drugs. Before this can be employed with respect to biomaterials, the role of individual factors (humoral and cellular) has to be studied. In this part of the investigation, the role of T cells was studied by use of T-cell-deficient (nude) rats and control (AO) rats. Hexamethylenediisocyanate-crosslinked dermal sheep collagen (HDSC) was selected as the test material. The results showed that T cells or T cell-related factors played a prominent role in the attraction of macrophages and the formation of giant cells, their antigen presentation, and their phagocytotic capacity. As a consequence, degradation of HDSC was strongly delayed. This study also showed that infiltration of fibroblasts and creation of stromal areas in HDSC was restricted to areas subjected to degradation. However, in time, absence of T cells resulted in increased formation and maturation of autologous rat collagen. Results obtained suggest that the inflammatory reaction to biomaterials might be modulated by controlling T-cell activation.

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Studies on the tumor‐promoting activity of biomaterials: Inhibition of metabolic cooperation by polyetherurethane and silicone

Cited by 26 publications

References 9 publications

Studies on the mechanisms of tumorigenesis induced by polyetherurethane in rats: Production of superoxide, tumor necrosis factor, and interleukin 1 from macrophages cultured on different polyetherurethanes

Studies on the mechanisms of tumorigenesis induced by polyetherurethane in rats: Production of superoxide, tumor necrosis factor, and interleukin 1 from macrophages cultured on different polyetherurethanes

Neural differentiation of midbrain cells on various protein‐immobilized polyethylene films

Modulation of the tissue reaction to biomaterials. II. The function of T cells in the inflammatory reaction to crosslinked collagen implanted in T-cell-deficient rats

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