Studies on the treatment of dermatophytic infections of glabrous skin by topical treatment alone or with combination of griseofulvin for comparison

Erbakan, N.; Or, Armas; Palali, Z.; Başaran, Erdal

doi:10.1007/bf02198757

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…The results of antifungal combinations in humans are reported in Table 3 . There were 25 papers describing 37 single case reports, one paper each describing 36 and 254 patients, respectively, and 3 clinical trials involving a total of 410 patients [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. Either paediatric or adult patients were represented.…”

Section: Resultsmentioning

confidence: 99%

“…In all patients, recovery was confirmed by clinical and mycological examination 3 months after healing [ 87 ]. One early observational study involving 254 patients with various forms of dermatophyte infections mainly due to Trichophyton spp., concluded that topical treatment (Wilkinson’s salve, iodized alcohol 5%, undecylenic acid derivatives, 5-bromo-4′-chlorosalicylanilides, tolnaftates) plus griseofulvin possibly enhances the healing capacity and shortens the time for treatment, but it has no effect in preventing reinfections [ 88 ]. One randomized study of toenail onychomycosis with matrix area involvement due to T. rubrum in most cases, compared amorolfine 5% nail lacquer once weekly for 24 weeks given with 200 mg of itraconazole once daily for 6 or 12 weeks vs. itraconazole alone given for 12 weeks [ 91 ].…”

Section: Resultsmentioning

confidence: 99%

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Antifungal Combinations in Dermatophytes

Brescini

Fioriti

Morroni

et al. 2021

JoF

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Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations against dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies and 31 articles referring to case reports or clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69% Trichophyton spp., 29% Microsporum spp., and 2% Epidermophyton floccosum). Combinations included two antifungal agents or an antifungal agent plus another chemical compound including plant extracts or essential oils, calcineurin inhibitors, peptides, disinfectant agents, and others. In general, drug combinations yielded variable results spanning from synergism to indifference. Antagonism was rarely seen. In over 700 patients with documented dermatophyte infections, an antifungal combination approach could be evaluated. The most frequent combination included a systemic antifungal agent administered orally (i.e., terbinafine, griseofulvin, or azole—mainly itraconazole) plus a topical medication (i.e., azole, terbinafine, ciclopirox, amorolfine) for several weeks. Clinical results indicate that association of antifungal agents is effective, and it might be useful to accelerate the clinical and microbiological healing of a superficial infection. Antifungal combinations in dermatophytes have gained considerable scientific interest over the years and, in consideration of the interesting results available so far, it is desirable to continue the research in this field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antifungal Combinations in Dermatophytes

Brescini

Fioriti

Morroni

et al. 2021

JoF

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“…In all patients recovery was confirmed by clinical and mycological examination 3 months after healing [87]. One early observational study involving 254 patients with various forms of dermatophyte infections mainly due to Tricophyton spp., concluded that topical treatment (Wilkinson's salve, iodized alcohol 5 %, undecylinic acid derivatives, 5-bromosalicyl-4-chtoranilides, tolnaphtates) plus griseofulvin possibly enhances the healing capacity and shortens the time for treatment, but it has no effect in preventing reinfections [88]. One randomized study of toenail onychomycosis with matrix area involvement due to T. rubrum in most cases, compared amorolfine 5% nail lacquer once weekly for 24 weeks given with 200 mg of itraconazole once daily for 6 or 12 weeks vs itraconazole alone given for 12 weeks [91].…”

Section: Clinical Casesmentioning

confidence: 99%

Antifungal Combinations in Dermatophytes

Brescini¹,

Fioriti²,

Morroni³

et al. 2021

Preprint

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Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations in dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies, and 31 articles referring to case reports/clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69% Trichophyton spp., 29% Microsporum spp., and 2% Epidermophyton floccosum). Combinations included two antifungal agents or an antifungal agent plus another chemical compound including plant extracts/essential oils, calcineurin inhibitors, peptides, disinfectant agents and others. In general, drug combinations yielded variable results spanning from synergism to indifference. Antagonism was rarely seen. In over 700 patients with documented dermatophyte infections an antifungal combination approach could be evaluated. The most frequent combination included a systemic antifungal agent administered orally (i.e.: azole [mainly itraconazole], terbinafine or griseofulvin) plus a topical medication (i.e.: azole, terbinafine, ciclopirox, amorolfine) for several weeks. Clinical results indicate that association of antifungal agents is effective, and it might be useful in accelerate the clinical and microbiological healing of a superficial infection. Antifungal combinations in dermatophytes have gained considerable scientific interest over the years and, in consideration of the interesting results available as far, it is desirable to continue the research in this field.

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Chapter 13. Antifungal Agents

Shadomy

Wagner

1975

Annual Reports in Medicinal Chemistry

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Studies on the treatment of dermatophytic infections of glabrous skin by topical treatment alone or with combination of griseofulvin for comparison

Cited by 3 publications

References 15 publications

Antifungal Combinations in Dermatophytes

Antifungal Combinations in Dermatophytes

Antifungal Combinations in Dermatophytes

Chapter 13. Antifungal Agents

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