Studies on the Toxicity of Alkyl Tin Compounds

Stoner, H. B.; Barnes, J. M.; Duff, Janet I.

doi:10.1111/j.1476-5381.1955.tb00053.x

Cited by 99 publications

(55 citation statements)

References 11 publications

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“…Muscular weakness and paralysis were as well observed (Alajouanine et al, 1958). Although neurologic effects of trimethyltin in rats, such as tremor, hyperexcitability, and aggression, were reported in the original studies of Stoner et al (1955) and Barnes and Stoner (1958), no histopathologic lesions were described until more than 20 years later. Brown et al (1979) and Bouldin et al (1981) observed necrosis of neurons in specific areas of the CNS in rats given several oral doses of 4 or 5 mg trimethyltin/kg body weight.…”

Section: Neurotoxicitymentioning

confidence: 98%

“…At least 100 of them died (Alajouanine et al, 1958;Barnes and Stoner, 1959). Since that time, the toxicology of the organotin compounds has received detailed attention (Stoner et al, 1955;Stoner, 1958, 1959;Barnes and Magee, 1958;Magee et al, 1957;Stoner, 1966).…”

Section: Growing Production and Concernmentioning

confidence: 99%

“…The toxic action of triethyltin on the CNS of rodents was first described by Stoner et al in 1955. In more detailed studies using adult rats, Magee et al (1957) reported that dietary concentrations of 20 mg triethyltin/kg feed induced interstitial edema of the white matter of the brain and spinal cord without obvious neuronal damage.…”

Section: Neurotoxicitymentioning

confidence: 99%

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Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

345

131

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As a consequence of the rapid expansion of the uses and applications of the organotin compounds, the concern about their environmental and health effects is increasing. The main subject of this overview is the current understanding of the mammalian toxicity of the organotin compounds. Four different types of target organ toxicity, namely neurotoxicity, hepatotoxicity, immunotoxicity, and cutaneous toxicity, are discussed in more detail. The effects of the organotin compounds on the mitochondfial and cellular level are summarized and discussed in relation to the mode of action of these compounds on the central nervous system, the liver and bile duct, the immune system, and the skin. © 1987 Academic Press, Inc. ORGANOTIN COMPOUNDS: APPLICATIONS AND TOXICITY Organotin CompoundsTin can be present as an element in a wide variety of both inorganic and organometallic compounds. Organometallic tin compounds or organotins are characterized by the presence of at least one covalent carbon-tin bond. Although tin may exist either in the Sn 2+ or in the Sn 4+ oxidation state, almost all organotins have a tetravalent structure. Depending on the number of organic moieties, the organotin compounds are classified as mono-, di-, tri-, and tetraorganotins. In compounds of industrial importance, methyl, butyl, octyl, and phenyl groups form the organic substituents, while the anion is usually chloride, fluoride, oxide, hydroxide, carboxylate, or thiolate. All alkyltin compounds refered to in this article contain unbranched saturated hydrocarbon side chains (n-alkyltins).

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Section: Neurotoxicitymentioning

confidence: 98%

Section: Growing Production and Concernmentioning

confidence: 99%

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Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

345

131

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“…The toxic components are dimethyltin chloride and trimethyltin chloride. Previous studies have reported that dimethyltin chloride is toxic to the liver and kidneys, whereas trimethyltin chloride damages the central nervous system [2][3][4] . The neurotoxicity of dialkyltin or trialkyltin compounds has been recognized in animal studies, but only a few descriptions of their human toxicity have been reported 1,[5][6][7][8][9][10][11][12][13][14] .…”

mentioning

confidence: 99%

A Case of Acute Organotin Poisoning

Yoo

Kim

Jeong

et al. 2007

Journal of Occupational Health

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“…Bu ilaçta kontaminant olarak bu-liman trictilkalay nedeniyle 217 kişi zehirlendi ve neticede yaklaşık 100 kişi öldü. Bu olaydan sonra organokalay bileşiklerinin toksik etkileri büyük bir dikkatle araştırılmıştır (48). Bununla birlikte organokalay bileşikleri ile ilgili zehirlenme olayları devam etmektedir.…”

Section: Organokalay Bileşiklerinin Insan Sağlığı üZerine Olan Etkileriunclassified

Organokalay Bileşiklerinin Yarattıkları Önemli Çevre Sorunları : Ecotoxicological Problems of Organotin Compounds

Duydu¹

1994

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Studies on the Toxicity of Alkyl Tin Compounds

Cited by 99 publications

References 11 publications

Biological activity of organotin compounds—An overview

Biological activity of organotin compounds—An overview

A Case of Acute Organotin Poisoning

Organokalay Bileşiklerinin Yarattıkları Önemli Çevre Sorunları : Ecotoxicological Problems of Organotin Compounds

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