Studies on the total synthesis of triptolide. II. the C-ring functionality of triptonide.

Frieze, Donna M.; Berchtold, Glenn A.; Blount, John F.

doi:10.1016/s0040-4039(01)85683-5

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“…Structurally, it has nine chiral centers, three successive epoxides and a butenolide. Since the pioneering works of Berchtold, Tahara and their co-workers [45,63–65], several racemic and/or asymmetric total syntheses of triptolide and its relatives have been carried out in many research groups.…”

Section: Reviewmentioning

confidence: 99%

A review of the total syntheses of triptolide

Zhang¹,

Xiao²,

Xu³

2019

Beilstein J. Org. Chem.

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Triptolide is a complex triepoxide diterpene natural product that has attracted considerable interest in the organic chemistry and medicinal chemistry societies due to its intriguing structural features and multiple promising biological activities. In this review, progress in the total syntheses of triptolide are systematically summarized. We hope to gain a better understanding of the field and provide constructive suggestions for future studies of triptolide.

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Section: Reviewmentioning

confidence: 99%