Studies on the structure of polysaccharides from the bark of Melia azadirachta.

Effect of Neem (Azadirachta indica) oil on the progressive growth of a spontaneous T cell lymphoma

“…Till date no one has reported the effect of neem oil on progression of any T cell tumor. Contradictory to the findings of Fujiwara (1982), our observation suggests an increased growth of DL in mice treated with neem oil. Intraperitoneal administration of neem oil was shown to accelerate DL growth and resulted in early death of DL-bearing mice compared to tumor-bearing mice not treated with neem oil.…”

“…Neem oil has been shown to have a modulatory effect on the immune system (Upadhyay et al, 1992) and similar nature of immunostimulation was also seen with neem leaf extract (Ray et al, 1996) and neem derived polysaccharides (Fujiwara et al, 1982). Inspite of these findings the effect of neem oil on tumor growth remains neglected.…”

“…The activity of neem with the crude extracts, their different fractions and active components have been studied (Koul et al, 2004). Neem oil has been shown to possess immunomodulatory properites (Upadhyay et al, 1992) and polysaccharides isolated from neem bark have shown to inhibit the growth of sarcoma 180 (Fujiwara et al, 1982). However, it remains unclear if products derived from neem oil can also alter the growth of a T-cell lymphoma and related antitumor immunity.…”

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

“…Neem (Azadirachta indica A. Juss) is a well known versatile medicinal plant that has a wide spectrum of biological activities including anti-inflammatory activity (33)(34)(35)(36)(37). The ethnopharmacological exploration and bioactivity testing of various neem compounds and extracts revealed its efficacy to prevent a wide variety of inflammatory disorders in infectious and non-infectious diseases (34, [37][38][39][40][41][42][43][44][45]. It is interesting to note that neem compounds show a beneficial effect in pathological conditions in which MIF-mediated pathologies are prevalent (6,10,11,14,16,17,21).…”

In Vitro Studies on the Effect of Azadirachta Indica Linn. In Lung Cancer A549 Cell Lines

“…The wood have several polysaccharide like cellulose, hemicellulose and lignin, where as wood oil consists of ß-sitosterol, cycloeucalenol and 24-methylenecyceloartenol. [8] The tree discharges a gum, which on hydrolysis yields, L-arabinose, L-fucose, D-galactose and D-glucoronic acid. The older tree exudes a sap containing free sugars (glucose, fructose, mannose and xylose), amino acids (alanine, aminobutyric acid, arginine, asparagines, asparticacid, glycine, norvaline, praline, etc.)…”