STUDIES ON THE ROLE OF GROWTH HORMONE IN PREGNANCY<sup>1</sup>

Beaton, George H.; Ryu, Mi Heh; McHenry, E. W.

doi:10.1210/endo-57-6-748

Cited by 18 publications

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“…-7r%f%-there is a relatively sharp gradient of activity between the portal and venous zones of the liver acinus [1]. Studies in vivo suggest that the activity of alanine aminotransferase in whole liver is under complex control by hormones that are suppressed after hypophysectomy [13,15,[21][22][23][24]. Hypophysectomy is associated with an increase in activity of alanine aminotransferase [13,15] that is partially reversed by growth-hormone replacement [13,15].…”

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Hypophysectomy does not alter the acinar zonation of gluconeogenesis or the mitochondrial redox state in rat liver

Tosh

Alberti

Agius

1989

Biochemical Journal

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The biochemical and functional heterogeneity of hepatocytes in different zones of the liver acinus may be related to the concentrations of hormones within the liver acinus. We examined the effects of hypophysectomy, which causes marked changes in plasma hormone levels and in activities of hepatic enzymes that are normally heterogeneously distributed, on the degree of metabolic zonation within the liver acinus. In hypophysectomized rats the activity of alanine aminotransferase was increased, but its normal zonation (predominance in the periportal zone) was preserved. The activity in cultured periportal and perivenous hepatocytes was increased by dexamethasone, but not by glucagon. Periportal hepatocytes from hypophysectomized rats expressed higher rates of gluconeogenesis in culture than did perivenous hepatocytes, irrespective of the absence or presence of dexamethasone, glucagon or insulin. Similar differences in rates of ketogenesis and in the mitochondrial redox state in response to glucagon were observed between periportal and perivenous hepatocytes from hypophysectomized rats as between cell populations from normal rats. Although hypophysectomy causes marked changes in hepatic enzyme activities, it does not alter the degree of zonation of alanine aminotransferase, gluconeogenesis or the mitochondrial redox state within the liver acinus.

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