Studies on the Role of Bacteria in Irreversible Hemorrhagic Shock in Dogs

Eg, Hardy; Gc, Morris; Em, Yow; Bw, Haynes; Me, Debakey

doi:10.1097/00000658-195403000-00004

Cited by 30 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absorption of endotoxins from the intestinal tract of mammals, both under physiological and pathological conditions, is a long-standing, but still current, problem. The majority of researchers could not demonstrate endotoxin absorption from the intestinal canal (2,3,7,10,13,17,24,31). However, as found by Rauss and co-workers (18-20), Ketyi (11), and Ocklitz and co-workers (15, 16), the perorally administered endotoxin, as an antigen, is able to produce a specific immunity.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Effect of Bile Acids on the Intestinal Absorption of Endotoxin in Rats

1969

View full text Add to dashboard Cite

The absorption of tritium-labeled Escherichia coli O89 Westphal-type endotoxin from the peritoneal cavity of rats was diminished by bile by 23% and by sodium deoxycholate by 47%, respectively. Practically, there is no endotoxin absorption from the intestinal tract of normal rats. The bile duct of rats was chronically cannulated for experimental purposes. A significant amount of perorally administered endotoxin absorbed from the intestinal canal into the blood in the rats treated thus. Absorption was demonstrated by the lethal effect of endotoxin on rats previously hypersensitized by lead acetate, and by the radioactivities found in the blood samples. The intestinal absorption of endotoxin in rats, rendered bile-deficient, may be prevented by sodium deoxycholate. Supported by their experimental findings, we emphasize the important role of bile acids in the defense mechanism of the macroorganism against bacterial endotoxins.

show abstract

Section: Discussionmentioning

confidence: 95%

“…Thus, the main problem in the elucidation of the pathogenesis of these enterotoxemias is the absorption of endotoxin from the intestines. Earlier studies on endotoxin absorption gave contradictory results (2,7,9,10,13,14,17,21,22,24,25,30,31).…”

mentioning

confidence: 94%

Effect of Bile Acids on the Intestinal Absorption of Endotoxin in Rats

1969

View full text Add to dashboard Cite

show abstract

“…For example, antibiotics have not always protected normal dogs in which shock has been induced (9), and in rats raised in bacteria-free situations, contrary to what might be expected shock occurred with the same traits as in rats taken from a common pen, and which were consequently, carriers o f intestinal bacterial flora (35,36).…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, there are other publications which deny the toxic bacterial factor as a cause o f irreversibility o f shock (9,35,36).…”

Section: Z a P A T A -O R T Iz And R G O N Z á L E Z -E N D E R Smentioning

confidence: 99%

Experimental Hemorrhagic Shock. Influence of Demethylchlortetracycline on Irreversibility

Zapata-Ortiz¹,

González-Enders²

1961

Chemotherapy

View full text Add to dashboard Cite

“…In spite of such reports, studies by Hardy et al and Lillehei showed no beneficial effects on the outcome of hemorrhagic shock resulting from pretreatment with antibiotics [8,12] [1967] demonstrated that blood and plasma from irreversibly shocked dogs were not lethal for mice rendered tenfold sensitive to E. coli endotoxin [23], Because of the known detoxifying properties of the liver, it was con sidered that under conditions of severe shock, toxins, whatever their source may be, concentrated within this organ. One might thus expect ex tracts of shocked hypoxic liver to be toxic and possibly to increase the susceptibility of shocked animals to irreversibility.…”

mentioning

confidence: 99%