Studies on the Relationship Between Sub-Clinical Ketosis and Liver Injuries Within the First Two Months of Lactation Period in High Producing

Nazifi, Saeed; Mohebbi‐Fani, Mehdi; Rowghani, E.; Behbood, M.R.

doi:10.3923/ijds.2008.29.35

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…These findings were in agreement with those reported by Sharma and Rakesh, (2001);Elitok et al, (2006); Yameogo et al, (2007). On the contrary, in agreement with Nazifi et al, (2008); Farag and Metwally, (2012) levels of NEFA and ketones were elevated markedly in ketosis affected buffaloes. This drop in glucose levels could be the result of energy deprivation, particularly in the early stages of lactation when the mammary gland has to use glucose at a high rate (Bremmer et al, 2000).…”

Section: Discussionsupporting

confidence: 92%

Effects of Ketosis and Hypocalcemia on The Biochemical Parameters and Subsequent Postpartum Reproductive Performance in Buffaloes

Ramadan

Yousef²,

Mahmoud³

et al. 2023

SVU-International Journal of Veterinary Sciences

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Water buffaloes (Bubalus bubalis) are mainly distributed in tropical and subtropical countries that include the Indian sub-continent and some Mediterranean countries such as Egypt. The transition period is the most stressful period for buffaloes, and it is considered as a turning point in the productive cycle from one lactation to the next and includes different metabolic, physiological, and nutritional changes. Metabolic disorders are common causes of lower productivity in buffaloes. Of these metabolic disorders, ketosis and hypocalcemia are most prevalent. This study aimed to study the ketosis-and hypocalcemia-related biochemical changes during the transition period and their impacts on the postpartum reproductive fertility in Buffaloes. Out of 120 total number of examined buffaloes, 40 buffaloes were used in this study; control group (n=10), hypocalcemia-affected (n=15), and ketosis-affected group (n=15). All buffaloes were subjected to thorough clinical and gynecological examination. Both urine and blood samples were collected from all groups. The amounts of ketone bodies were detected in urine. Biochemical parameters were evaluated including concentrations of glucose, triglycerides, cholesterol, non-esterified fatty acids (NEFA), calcium, phosphorus, sodium, potassium, albumin, total protein, urea and progesterone hormone (P4) in blood the following time-points (2-weeks prepartum, 1-week prepartum, partum, 1-week postpartum, and 2-weeks postpartum). Both hypocalcemia-and ketosis affected buffaloes had lower glucose, phosphorus, sodium and albumin and higher NEFA than control group. Hypocalcemia-affected buffaloes showed lower calcium and higher total protein than control group, while, ketosis-affected buffaloes showed lower cholesterol and total protein than control group. Moreover, metabolic disorders negatively affected the reproductive performance. Both ketosis and hypocalcemia significantly prolonged the duration to first estrus, increased both the number of days-open and the number of services per conception.

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Section: Discussionsupporting

confidence: 92%

Effects of Ketosis and Hypocalcemia on The Biochemical Parameters and Subsequent Postpartum Reproductive Performance in Buffaloes

Ramadan

Yousef²,

Mahmoud³

et al. 2023

SVU-International Journal of Veterinary Sciences

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“…Stage of lactation-wise prevalence of ketosis (Table 3) between 0-1, 1-2, 2-3, 3-4 and 4-5 month after parturition was 37.50, 45, 10, 5 and 2.50 per cent respectively. Similar findings were given by (Chakrabarti, 2006;Sharma, 2006;Teli and Ali, 2007;Radostitis et al, 2007;Nazifi et al, 2008), who have reported maximum cases within one month after parturition. These figures suggested that prevalence of clinical ketosis among lactating cows were maximum in first two months of lactation, when the animals are in peak phase of production.…”

Section: Lactation-wise Prevalencesupporting

confidence: 84%

Prevalence and Clinical Manifestations of Ketosis in Cows in and Around Bikaner

Nazeer¹,

Kumar²,

Jaiswal³

et al. 2019

Int.J.Curr.Microbiol.App.Sci

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“…It can be speculated that the adipose tissue of ketotic cows is more prominent by PPARαmediated regulation of adipocytic oxidative factors. Moreover, STAT5 is involved in GH-regulated lipolysis (52). After GH stimulates STAT5 activation in adipose tissue, phosphorylated STAT5 dimers are transferred into the nucleus to bind to DNA target sequences to regulate a series of fat synthesis genes (50)(51)(52)(53).…”

Section: Effects Of Lft Indices In Ketotic and Healthy Dairy Cows Dur...mentioning

confidence: 99%

“…Moreover, STAT5 is involved in GH-regulated lipolysis (52). After GH stimulates STAT5 activation in adipose tissue, phosphorylated STAT5 dimers are transferred into the nucleus to bind to DNA target sequences to regulate a series of fat synthesis genes (50)(51)(52)(53). The PPARα is a downstream molecule of the JAK2-STAT5A pathway and its expression is inhibited in the liver.…”

Section: Effects Of Lft Indices In Ketotic and Healthy Dairy Cows Dur...mentioning

confidence: 99%

Differentiation of Subclinical Ketosis and Liver Function Test Indices in Adipose Tissues Associated With Hyperketonemia in Postpartum Dairy Cattle

Mohsin

et al. 2022

Front. Vet. Sci.

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Past studies suggested that during early lactation and the transition period, higher plasma growth hormone (GH) levels in subclinical ketosis (SCK) might involve the initiation of body adipose tissues mobilization, resulting in metabolic disorders in ruminants particularly hyperketonemia. The upregulated GH mRNA expression in adipose tissue may take part in the adipolysis process in SCK-affected cows that paves a way for study further. This study aimed to characterize the plasma levels of GH, β-hydroxybutyrate acid (BHBA) and non-esterified fatty acid (NEFA) and glucose (GLu) in ketotic cows and healthy control (CON) cows; to measure the liver function test (LFT) indices in ketotic and healthy CON cows, and finally the quantitative real-time PCR (qRT-PCR) assay of candidate genes expressed in adipose tissues of ketotic and healthy CON cows during 0 to 7 week postpartum. Three experiments were conducted. Experiment-1 involved 21 Holstein cows weighing 500–600 kg with 2–5 parities. Results showed that GH, BHBA, and NEFA levels in ketotic cows were significantly higher and the GLu level significantly lower. Pearson's correlation analysis revealed a significant positive correlation of GH with BHBA, NEFA, and GLu in ketotic and healthy CON cows. In experiment-2, dynamic monitoring of LFT indices namely, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin (ALB), globulin (GLOB) and albumin/globulin (A/G) were examined. The TBIL, DBIL, and GGT indices were significantly higher in ketotic cows and TP was significantly lower. In experiment-3, mRNA expression levels of GHR and peroxisome-proliferator-activated receptor alpha (PPARα) genes in adipose tissue were significantly upregulated in ketotic cows. However, the mRNA expression of insulin-like growth factor-I (IGF-1), insulin-like growth factor-I receptor (IGF-1R), and sterol regulatory element-binding protein-1c (SREBP-1c) genes in adipose tissue were downregulated in ketotic cows. Our study concluded that during postpartum, higher plasma GH levels in SCK cows might involve the initiation of body adipose tissue mobilization, resulting in hyperketonemia.

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Studies on the Relationship Between Sub-Clinical Ketosis and Liver Injuries Within the First Two Months of Lactation Period in High Producing

Cited by 9 publications

References 30 publications

Effects of Ketosis and Hypocalcemia on The Biochemical Parameters and Subsequent Postpartum Reproductive Performance in Buffaloes

Effects of Ketosis and Hypocalcemia on The Biochemical Parameters and Subsequent Postpartum Reproductive Performance in Buffaloes

Prevalence and Clinical Manifestations of Ketosis in Cows in and Around Bikaner

Differentiation of Subclinical Ketosis and Liver Function Test Indices in Adipose Tissues Associated With Hyperketonemia in Postpartum Dairy Cattle

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