Studies on the Relation of the Thyroid to Pancreatic Diabetes in Dogs

Friedman, G; Gottesman, Julius

doi:10.1001/jama.1922.02640150040010

Cited by 2 publications

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“…1971 hydrate metabolism (Eppinger, Falta and Rudinger 1908). Hyperthyroidism induces an aggravation of the diabetic condition in the human (Allen 1922), Friedmann andGottesmann 1922, Wilder 1926).…”

Section: Introductionmentioning

confidence: 99%

Studies on the Effect of Hyperthyroidism on the Insulin Response to Hyperglycemia in the Dog

et al. 1971

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247MilmJIn, A.E., J.A. RusseU: Some effects of purified growth hormone on carbohydrate metabolism in the rat. Endocrinology 47: 114 (1950) Park, C.R., D.H. Brown, M. Comblath, W.H. Daughaday, M.E. Krahl: The effect of growth hormone on glucose up-take by the isolated rat diaphragrn. J. biol Chern. 197: 151 (1952) Sehaleh, D.S., D.M. Kipnis: Abnormalities in carbohydrate tolerance associated with elevated nonesterified fatty acids. SummaryW,e studied the effect of hyperthyroidism on the insulin response to hyperglycemia in the dog during a standard oral (OGm and intravenous (lVGTn glucose tolerance test. The development of the hyperthyroid condition was elicited through chronic subcutaneous I-thyroxin treatment at one of the following doses: 0.5 and 100"1 Ikg body weightl day, for 10-12 days. Blood sugar and serum immunoreactive insulin (IR!) were measuredNormal fasting blood sugar and serum IRI levels remained unchanged in the dog, despite the thyroxin treatment. The rate of disappearance of intravenously injected glucose from blood was normal as weil However, a shorter tban normal, 50% diminished and late insulin response to glucose was found in the hyperthyroid group (both thyroxin levels).The blood sugar eurve during the OGTT was found to be normal during the mild degree of hyperthyroidism, which was accompanied with an earlier tban normal and moderately rnaintained insulin response to hyperglycemia, whose maximum was 25% above normal The blood sugar curve during the OGrr was normal in the severely hyperthyroid dogs only for the 60 minute-period following glucose administration. However, the blood sugar was still above controllevels 30 minutes later in this group. A definitely reduced (low,late and shorter than normal) insulin response to hyperglycemia was found after thyroxin treatment (high level), Horm. Metab. Res. 3: 247-251 (1971) K e y -W 0 r d s: Hyperthyroid Dog -Serum Immunoreaclive Insulin -Oral Glucose Tolerance Test -Intravenous Glucose Tolerance Test

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Section: Introductionmentioning

confidence: 99%