Studies on the Preventive Inoculation Against Syphilis

Tani, Tomoji; Inoue, Raita; Asano, Osamu

doi:10.7883/yoken1948.4.71

Cited by 13 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results, therefore, of three groups of investigators are of interest, viz. Tani, Inoue, and Asano (1951), Miller (1967, 1973, Metzger and others (1969), and Metzger and Smog6r (1969). Tani and others (1951) studied the effect on protective immunity against T. pallidum in rabbits immunized by carbolic acid saline suspensions of T. pallidum.…”

Section: Discussionmentioning

confidence: 99%

Immunity in syphilis. Studies in active immunity.

Al-Samarrai¹,

Henderson²

1976

Sexually Transmitted Infections

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Immunity in syphilis. Studies in active immunity.

Al-Samarrai¹,

Henderson²

1976

Sexually Transmitted Infections

View full text Add to dashboard Cite

“…The main reason for these failures lies undoubtedly in lack of information on the nature of the immunogenic factor of the treponemes and its situation in the treponemal body. Tani, Inoue, and Asano (1951) believed that the immunizng component of the treponeme was (2) No lesions at sites of challenge and lymph node transfers negative. situated deep in the body of the organism and must be "unmasked" by removing a covering material before the component is immunogenic.…”

Section: Serological Responsementioning

confidence: 99%

Immunogenic properties of the protein component of Treponema pallidum.

Metzger¹,

Michalska²,

Podwińska³

et al. 1969

Sexually Transmitted Infections

View full text Add to dashboard Cite

In a previous paper (Metzger and Podwiinska, 1967) evidence was presented that the development of agglutinability which occurs in ageing suspensions of T. pallidum (Hardy andNell, 1955, 1957; Metzger and Podwinska, 1965) (2) Each batch of treponeme suspensions under (i), (ii), and (iii), prepared anew for every immunization week, was tested for virulence by injecting 01 ml. of the suspension containing 29 million organisms at each of four sites on the shaven back of a rabbit, and 0 5 ml., 299

show abstract

“…Protection has been demonstrated in the rabbit model by using complicated immunization protocols with gamma-irradiated, antiformin-treated, or 4°C "aged" treponemes (34,35,41). Although these regimens are impractical and not suitable for humans, they do demonstrate that protective immunity by vaccination is attainable.…”

mentioning

confidence: 99%

Immunization with the N-Terminal Portion ofTreponema pallidumRepeat Protein K Attenuates Syphilitic Lesion Development in the Rabbit Model

Morgan¹,

Lukehart

Voorhis

2002

Infect Immun

View full text Add to dashboard Cite

When used as an immunogen, Treponema pallidum repeat protein K (TprK) has been shown to attenuate syphilitic lesions upon homologous intradermal challenge in the rabbit model. To further explore this protein as a potential vaccine component, we sought to identify the immunogenic regions of TprK. The abilities of three recombinant peptides encompassing TprK to elicit T-and B-cell responses and to protect against challenge were examined. All three fragments elicited proliferative responses from splenocytes taken from infected rabbits. However, enzyme-linked immunosorbent assays indicated that only fragments 1 and 3 were consistently recognized by antisera from infected rabbits. Each fragment was also used to immunize rabbits that were subsequently challenged intradermally with infectious T. pallidum. All lesions on unimmunized control rabbits ulcerated and contained treponemes, while the lesions on rabbits immunized with fragment 1 were the least likely to have detectable treponemes (25%) and the least likely to ulcerate (37.5%). The lesions on rabbits immunized with fragment 3 showed intermediate results, and rabbits immunized with fragment 2 were the most likely of all those on immunized rabbits to have detectable treponemes (91.7%) and to ulcerate (66.7%). These results demonstrate that epitopes in fragment 1 are recognized by T cells and antibodies during infection and that immunization with this portion of TprK most effectively attenuates syphilitic lesion development.

show abstract

Studies on the Preventive Inoculation Against Syphilis

Cited by 13 publications

References 11 publications

Immunity in syphilis. Studies in active immunity.

Immunity in syphilis. Studies in active immunity.

Immunogenic properties of the protein component of Treponema pallidum.

Immunization with the N-Terminal Portion ofTreponema pallidumRepeat Protein K Attenuates Syphilitic Lesion Development in the Rabbit Model

Contact Info

Product

Resources

About