Studies on the Prevention of Cholesterol Atherosclerosis in Rabbits

Turner, Kenneth B.

doi:10.1084/jem.58.1.115

Cited by 71 publications

(10 citation statements)

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“…Rabbits fed with cholesterol and with either desiccated thyroid or iodine showed an absence of atherosclerotic lesions. Furthermore, average blood cholesterol levels of these animals were significantly lower than the group fed with a cholesterol-rich diet and T4 [6]. It is also reported that treatment of dyslipidemia with T4 had been limited to hypothyroid and subclinical hypothyroid subjects and no curative effects on euthyroid patients with cardiovascular diseases or dyslipidemia [7].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

Zhao

Yan

Sun

et al. 2010

Biol Trace Elem Res

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The present study has been designed to investigate the impact of dietary iodine intake on lipid metabolism in mice, including iodine deficiency and iodine excess. Different amounts of iodine mixed in the drinking water were continuously administered to mice. The body weights and the levels of urinary iodine were measured 8 months after the treatment. Thyroid hormones in the serum were detected by chemiluminescence immunoassay. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-C) were determined enzymatically by automatic analyzer. Results showed that the urine iodine concentrations paralleled the amounts of iodine intakes. No statistical differences of body weights among different groups were found. The levels of thyroid hormones were dramatically decreased in iodine deficiency while no significant differences were found between iodine excess groups and normal iodine group. In iodine deficiency groups, the levels of TG, TC, and LDL were increased at varying degrees. In iodine excess groups, the levels of TG in the male mice and the levels of TC in the female mice were much lower than normal iodine group. In conclusion, dietary iodine intake may affect the metabolism of serum lipids. Hypothyroid function induced by iodine deficiency may be responsible for the changes of lipids. Higher iodine intake might benefit lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

Zhao

Yan

Sun

et al. 2010

Biol Trace Elem Res

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“…On the other hand, it has also been observed in a variety of studies that the serum cholesterol/phospholipid ratio is of importance in the genesis of atherosclerosis and the results of the present experiment are explicable on the assumption that the more normal ratio in the cortisone-treated rabbits of group 2 protected them partially against the development of atherosclerosis. The effect on the cholesterol levels is analogous to that occurring in experiments employing thyroid, potassium iodide, and similar substances (22)(23)(24)(25). The effect on the phospholipids is analogous to that seen in experiments with alloxan diabetes, tween 80, and similar substances.…”

Section: Discussionmentioning

confidence: 57%

“…Elevation of the serum cholesterol in normal animals can be caused by agents such as tween 80 or triton A 20 or the diabetic state caused by alloxan (3-8), but they do not depress the hypercholesterolemia resulting from cholesterol feeding. Similarly, treatment with thyroid hormone or iodides (22)(23)(24)(25) will reduce the hypercholesterolemia of cholesterol feeding but it will not elevate the serum cholesterol of normal rabbits that are not fed cholesterol. The effect of cortisone on the serum cholesterol is singular and its mechanism or mediation remains obscure.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cortisone on the Serum Lipids and on the Development of Experimental Cholesterol Atherosclerosis in the Rabbit

Gordon

Kobernick

McMillan

et al. 1954

Journal of Experimental Medicine

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An experiment was performed to determine the effect of cortisone on the serum lipids and on the development of experimental cholesterol atherosclerosis in the rabbit. Litter mate rabbits of the same sex were employed; both sexes were represented in the experiment. The report is based upon four experimental groups comprising (1) 12 rabbits fed cholesterol and treated with cortisone vehicle; (2) 12 rabbits fed cholesterol and treated daily with cortisone; (3) 11 rabbits treated with cortisone; and (4) 7 rabbits that received cortisone vehicle. It was observed that: (1) There was less aortic atherosclerosis in the cholesterol-fed cortisone-treated rabbits as judged by both morphological and chemical means than in the rabbits fed cholesterol without cortisone treatment. (2) Cortisone depressed appreciably the hypercholesterolemia resulting from the feeding of cholesterol to rabbits. (3) Cortisone treatment caused a moderate hypercholesterolemia in normal rabbits. (4) Cortisone caused a moderate increase in serum lipid phosphorus equal to that produced by cholesterol feeding alone. (5) The combination of cholesterol feeding and cortisone did not result in a higher phospholipidemia than either one of these agents alone. (6) Cortisone caused a great increase in serum-neutral fat; it was not apparent whether cholesterol feeding affected the neutral fat lipemia due to cortisone treatment alone. (7) The total cholesterol to lipid phosphorus ratio was about normal in the rabbits that received cortisone only. It was doubled in the animals receiving both cholesterol and cortisone, and it was increased about four times in those that received only cholesterol. The significance of the alterations in the serum lipids induced by cortisone is discussed in relation to the inhibition of the development of aortic atherosclerosis that occurred in the cholesterol-fed rabbits treated with cortisone.

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“…CHD is apparently commoner in South Asians (India, Pakistan, Bangladesh and Sri Lanka) in Britain than in general population, despite lower levels of several classic coronary risk factors. We expected that being of South Asian ethnicity may confer an elevated risk factor for cardiovascular disease (Kocher, 1883;Turner, 1933). These geographic differences in lesion distribution within similar ethnic groups strongly suggest that environmental conditions may exert more influence than do racial characteristics on symptomatic atherosclerosis.…”

Section: Facts Difficult To Explain By Current Theoriesmentioning

confidence: 99%

Chromosomal Q-Heterochromatin and Atherosclerosis

Ibraimov¹

2017

JMBR

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We suppose that at study of the pathogenesis of atherosclerosis, it is possible that some evolutionary aspects of the problem are missed. This aspect is related to the peculiarity of human adaptation to climatic geographic conditions of Eurasia, which differ significantly from the climate of East Africa, where Homo sapiens was formed as a tropical biological species and so it has remained to this day. A hypothesis has been put forward that the pathogenesis of atherosclerosis is associated with some previously unknown features of the genome and the physical properties of the human body that arose in the process of its adaptation to a mild and cold climate. These adaptive genetic changes that have contributed to the development (settling) by Homo sapiens of non-tropical, including cold and high mountain areas of the Earth, resulted to the fact that a man became the single species vulnerable (predisposed) to atherosclerosis.Atherosclerosis is apparently a purely human disease that appeared after adaptation of man to climatic conditions of temperate and northern latitudes of the northern hemisphere. The type of vessels (arteries or veins) and the site of their lumen have no role in the development of atherosclerotic changes. The primary and main causative factor in the development of atherosclerosis is blood temperature. The degree of blood cooling in the lungs depends on geographical latitudes and altitude above sea-level of the site of permanent residence of man. The preclinical stage of atherosclerosis may develop into a pathological form predominantly in individuals in the genome of which the amount of chromosomal Q-heterochromatin material is higher than its mean value per individual in the population.

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Studies on the Prevention of Cholesterol Atherosclerosis in Rabbits

Cited by 71 publications

References 0 publications

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

The Effect of Cortisone on the Serum Lipids and on the Development of Experimental Cholesterol Atherosclerosis in the Rabbit

Chromosomal Q-Heterochromatin and Atherosclerosis

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