Studies on the Preparation of¹¹³Sn-^113mIn Generators

Studies of Flerovium and Element 115 Homologs with Macrocyclic Extractants

“…Under the operating conditions of the generator, the 232 U will eventually bleed off the column; however, 228 Th and the daughters with higher Z 212 Pb remain strongly sorbed, Table 14. Due to the 69.8 year half-life of 232 U and the long 1.912 year half-life of 228 Th the bleeding of the 232 U, even if all in one 2 mL 212 Pb elution, will be unable to grow enough 212 Pb into solution to be detected over the approximately 3 hour experimental time frames. However, if 228 Th were to breakthrough, the generator would slowly degrade and detectable amounts of 212 Pb would grow into the experimental solutions during the 3 hour time frames.…”

“…The production methods of carrier-free Sn isotopes in literature are based on the isolation of 113,110 Sn in the production of 113m,110 In generators for radiopharmaceutical applications [212,213]. The production of carrier-free Hg has been described from high energy reactions designed to produce a packet of different radionuclides through the bombardment of Au targets with 7 Li and 12 C beams and subsequent separation of the carrier-free products from the excess Au [214].…”

“…As mentioned above a convenient way to obtain carrier-free Pb and Bi isotopes is through the preparation of an isotope generator based on the natural decay chains, Figure 51. After allowing approximately 7 half-lives of 212 Pb to pass (74.5 hr, time it takes for > 99% of activity to grow to equilibrium), the generator was eluted with 10, 1-mL fractions of 2 M HCl, each collected in a 15 mL centrifuge tube (same geometry as the stock solution). These solutions were monitored by HPGe gamma spectroscopy to determine the elution behavior of Pb from the generator.…”

“…For the purpose of performing the experiments presented in this dissertation, legacy 207 Bi material from LLNL was used as a source of Bi, however, it is possible to change the elution concentration on the generator to 0.5 M HCl and elute 212 Bi while leaving 212 Pb on the column.…”

“…Carrier-free Pb and Bi isotopes were obtained from development of a novel generator based on cation exchange chromatography using the 232 U parent to generate 212 Pb and 212 Bi.…”