Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of<i>Phyllanthus niruri</i>

Okoli, C. O.; Obidike, Ifeoma; Ezike, Adaobi Chioma; Akah, P. A.; Salawu, Oluwakanyinsola Adeola

doi:10.3109/13880209.2010.501456

Cited by 70 publications

(38 citation statements)

References 33 publications

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“…P. niruri was also reported to display anticarcinogenic [10], hypolipidemic [11], hepatoprotective [12], anti-inflammatory [13], and antiplasmodial [14] effects as well as an effective treatment for hemorrhagic cystitis [15]. Recent studies have also revealed antidiabetic [16] and antioxidant properties of this herbal extract [9] both in vivo and in vitro .…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Giribabu

Rao

Kumar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and in vitro antioxidant activity of P. niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney. Results. Treatment of diabetic male rats with P. niruri leaf aqueous extract (200 and 400 mg/kg) for 28 consecutive days prevents the increase in the amount of lipid peroxidation (LPO) product, malondialdehyde (MDA), and the diminution of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity levels in the kidney of diabetic rats. The amount of LPO showed strong negative correlation with SOD, CAT, and GPx activity levels. P. niruri leaf aqueous extract exhibits in vitro antioxidant activity with IC50 slightly lower than ascorbic acid. Phytochemical screening of plant extract indicates the presence of polyphenols. Conclusion. P. niruri leaf extract protects the kidney from oxidative stress induced by diabetes.

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Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Giribabu

Rao

Kumar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Studies have shown that P. niruri possesses antiviral (20), hepatoprotective (27,30), antihyperuricemic (18), lipid-lowering (12), antimalarial (31) and antiplasmodial (19), antinociceptive (17,22), antispasmodic (13), hypoglycemic, and antidiabetic (23,24) activities.…”

Section: Introductionmentioning

confidence: 99%

“…It is widely used in Asia, Africa, and South America for its vast therapeutic effects (24), Antiinflammatory effects of P. niruri aerial parts 257 to manage diabetes, constipation, fever, malaria, jaundice, hepatitis B, dysentery, gonorrhea, syphilis, tuberculosis, cough, influenza, diarrhea, vaginitis, tumors, and kidney stones (23,25,29). In Ayurveda, a decoction of the plant is administered orally for the treatment of asthma and diabetes (9).…”

Section: Introductionmentioning

confidence: 99%

Extracts ofPhyllanthus niruriAerial Parts Suppress Acute and Chronic Inflammation in Murine Models

Okoli

Nwezza

Ezike

2014

Journal of Herbs, Spices & Medicinal Plants

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The effect of methanol extract (ME), dichloromethane (DCMF), and methanol (MF) fractions of aerial parts of Phyllanthus niruri (Euphorbiacaeae) on acute and chronic inflammation were studied. An acute toxicity test in mice was used to establish an oral LD 50 >5,000 mg.kg −1 for ME. The ME and fractions inhibited the development of topical edema in the mouse ear and systemic edema of the rat paw, granuloma tissue growth, and the global edematous response to formaldehyde. The DCMF showed the greatest inhibitory effect in all the models, suggesting that the anti-inflammatory effects may be attributable to the alkaloids, resins, sterols, and terpenes contained in the fraction.

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“…Although no report on P. niruri having anti-lipase activity, a few reports indirectly stated the ability of this plant as anti-obesity agent. The anti-diabetic action of P. niruri extract has been studied by many researchers [42][43][44][45]. Okoli et al [44] reported the methanolic extract of aerial parts of P. niruri showed significant blood glucose lowering and glycemic control in diabetes.…”

Section: Lipase-inhibition Of Crude Plant Extractsmentioning

confidence: 99%

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

Alias¹,

Leow²,

Ali³

et al. 2017

AOWMC

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Natural products are a vast source of potential compounds that can be developed as anti-obesity agent. One of the mechanisms of anti-obesity agents is inhibition of pancreatic lipase. Assay of 24 crude extracts for their in vitro activity against porcine pancreatic lipase (PPL) detected four extracts demonstrating high (>70%) inhibition, seven extracts had medium (30-70%) inhibition and the remaining 13 extracts exhibited low (<30%) inhibition when incubated with PPL at a concentration of 500 µg/ml for 10 min at 37°C. Phyllanthus niruri extract displayed the most potent PPL inhibitor, followed by Orthosiphon stamineus, Murraya paniculata and Averrhoa bilimbi with the IC50 value of 27.7<34.7< 41.5<55.2 µg/ml, respectively. P. niruri & O. stamineus (the best two extracts) showed noncompetitive and uncompetitive inhibition, respectively. P. niruri & O. stamineus displayed total phenolic content of 431.0 ± 0.01 and 103.0 ± 0.01 mg GAE/g dry extract, while total flavonoid content of 14.8 ± 0.07 and 21.6 ± 0.03 mg QE/g dry extract, respectively. Both P. niruri & O. stamineus extracts showed high antioxidant activity, with EC50 values of 8.4 and 26.3 µg/ml, respectively. The results suggest that P. niruri & O. stamineus may be beneficial for obesity treatment via pancreatic lipase inhibition action.

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Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts ofPhyllanthus niruri

Abstract: These findings suggest that aerial parts of P. niruri may owe their blood glucose lowering properties to inhibition of glucose absorption and enhancement of glucose storage.

Cited by 70 publications

References 33 publications

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Extracts ofPhyllanthus niruriAerial Parts Suppress Acute and Chronic Inflammation in Murine Models

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

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