Studies on the Physiologic Hypoglycemia of Newborns

Stur, O

doi:10.1159/000239886

Cited by 7 publications

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“…Stur (1964) suggested that the glucose values of blood obtained by heel stab were falsely low due to peripheral stasis, but Cornblath, Levin, and Gordon (1956) have shown that heel-prick blood has a 'true' sugar content similar to that of femoral artery blood. The findings of Edwards (1964) in calves and of Scopes (1964) in babies suggest a resistance of the brain of the neonate to hypoglycaemia, dependent upon its ability to metabolize lactate, symptoms being absent as long as the lactate level is adequate.…”

Section: Resultsmentioning

confidence: 99%

Association of hypoglycaemia with symptoms in the newborn.

Griffiths¹

1968

Archives of Disease in Childhood

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Section: Resultsmentioning

confidence: 99%

Association of hypoglycaemia with symptoms in the newborn.

Griffiths¹

1968

Archives of Disease in Childhood

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“…Both Foster (1923) and Somogyi (1948) recommended that the limb be warmed before capillary blood was obtained, but the object of this manceuvre was rather to increase the blood flow than to arterialize the blood. It has recently been demonstrated in infants with impaired skin circulation that the glucose concentration of capillary blood drawn from a heel-stab may be significantly lower than the glucose concentration of blood in the inferior vena cava (Stur, 1964).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Brown and Wallis (1963) suspected that hypoglycaemia might be associated with depleted glycogen stores, a suspicion borne out by Shelley's (1964) finding of 'unexpectedly low' tissue carbohydrate concentrations in infants who were small for duration of gestation, and they, therefore, avoided the use of glucocorticoids and corticotrophin on the grounds that these drugs might aggravate such depletion. Cortisone acetate had no effect on the hypoglycaemia of 4 infants studied by Stur (1964), but Creery (1963) stated that oral glucose combined with 25 mg. hydrocortisone by intramuscular injection was a safe and reliable means of treating neonatal hypoglycaemia, though oral glucose alone was ineffective.…”

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Blood glucose concentration in the perinatal period.

Russell¹

1966

Archives of Disease in Childhood

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“…The diagnosis depends on the demonstration that the administration of intravenous glucose, in the presence of a low blood glucose, rapidly abolishes the symptoms. Caution is needed in interpreting blood sugar levels in the newborn because more non-glucose reducing substances are present than in older children (Haworth, 1965) and because estimations on capillary blood may be lower than those on central venous blood, perhaps because peripheral stasis may permit more glycolysis (Stur, 1964).…”

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Hypoglycaemia in childhood

Wood

Mann

1966

Postgraduate Medical Journal

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HYPOGLYCAEMIA in children may cause listlessness, inattention, pallor, stupor, convulsions and coma, which may be accompanied by tachycardia and sweating. Such non-specific symptoms as cyanotic attacks, reluctance to feed, irritability, convulsions, jittery limb movements and depression of the Moro reflex may occur in the hypoglycaemic newborn infant. A major part of these clinical patterns arises from the neuroglycopenia which is caused by hypoglycaemia.Hypoglycaemia has been recognised in childhood for over forty years (Ross and Josephs, 1924) and yet its true incidence in the newborn and older child is still difficult to assess today.Forty cases occurred amongst children of all ages in a one hundred and thirty bed unit over a twelve year period (McQuarrie, 1954) and twelve neonatal cases were found among six thousand newborn infants (Neligan, Robson and Walton, 1963). The incidence of symptomatic hypoglycaemia has been found to be no less than 6 % among premature infants, and as high as 15% in infants of birth weight less than the fiftieth percentile for gestational age (Wybregt, Reisner, Patel, Nellhaus and Comblath, 1964).Many different methods of blood sugar estimation have been used, and early less specific reduction methods (Folin and Wu 1920;Hagedorn and Jensen, 1923) tended to give higher figures than more specific reduction methods (Somogyi, 1952) and the glucose oxidase method (Marks, 1959). It is therefore difficult to define hypoglycaemia in terms of a blood glucose level. There is little doubt that the threshold for symptoms of neuroglycopenia varies from patient and from time to time. In the newborn a blood glucose level of under 20 mg./ 100 ml. or even below 10 mg./100 ml. may occasionally occur without symptoms, and many older children are not affected unless the level is under 40 mg./100 ml.Endocrine deficiencies causing hypoglycaemia are rare in childhood. Fasting hypoglycaemia was found in 29.3% of seventy-five cases of hypopituitarism, and hypoglycaemic symptoms occured in 9.7 %. In 37.5 % of this series hypoglycaemia followed a glucose load and 66.7 % were sensitive to insulin (Brasel, Wright, Wilkins and Blizzard, 1965). The

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Studies on the Physiologic Hypoglycemia of Newborns

Cited by 7 publications

References 0 publications

Association of hypoglycaemia with symptoms in the newborn.

Association of hypoglycaemia with symptoms in the newborn.

Blood glucose concentration in the perinatal period.

Hypoglycaemia in childhood

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