Studies on the Physical Dependence Liability of Analgesics 4th Report: Electron Microscopic Study on Intramitochondrial Structure of Zona Fasciculata Cells in Adrenal Cortex in Codeine Addicted Rats

Yano, Ichiro; Masuda, Yasusuke; Nishino, Hitoo; Yamamoto, Hiroyuki; Murano, Tadashi

doi:10.1016/s0021-5198(19)31566-5

Japanese Journal of Pharmacology

1973

DOI: 10.1016/s0021-5198(19)31566-5

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Studies on the Physical Dependence Liability of Analgesics 4th Report: Electron Microscopic Study on Intramitochondrial Structure of Zona Fasciculata Cells in Adrenal Cortex in Codeine Addicted Rats

Ichiro Yano¹,

Yasusuke Masuda²,

Hitoo Nishino³

et al.

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1978

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Studies on the Physical Dependence Potential of Analgesics

Murano¹,

Senda²,

Yamamoto³

et al. 1978

Japanese Journal of Pharmacology

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Abstract-influence of morphine on the fine structure of mitochondria in the cell of zona fasciculata of adrenal cortex in mice treated chronically with morphine pellets was studied using the electron microscope. The transformation of mitochondrial structure was observed 12 hours after morphine pellet implantation and the degree of transformation reached a maximum at 48 hours. These changes, however, disappeared within 4 days. On the 4th day after implantation, removal of the pellet or levallorphan challenge resulted in alteration of the mitochondria with evidence of withdrawal syn drome. Reinjection of morphine to the mice immediately after removal of the pellet, however, prevented the appearance of such mitochondrial transformation. Chlorpro mazine or sodium pentobarbital did not affect on the transformation of mitochondria.

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Studies on the Physical Dependence Potential of Analgesics

Murano¹,

Senda²,

Yamamoto³

et al. 1978

Japanese Journal of Pharmacology

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Studies on the Physical Dependence Liability of Analgesics 4th Report: Electron Microscopic Study on Intramitochondrial Structure of Zona Fasciculata Cells in Adrenal Cortex in Codeine Addicted Rats

Cited by 1 publication

References 5 publications

Studies on the Physical Dependence Potential of Analgesics

Studies on the Physical Dependence Potential of Analgesics

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