Studies on the Peripheral Vascular Physiology of Patients with Atopic Dermatitis

Skin Sensitivity to Histamine in Eczema and Psoriasis

“…This is in conformity with observations by other writers (4,6,9,10,7,8). Our cases were too few, however, to demonstrate significant differences from the control groups.…”

“…In earlier studies it was shown that the exudatory response in the skin of patients with atopic dermatitis (4, 6, 9, 10) or neurodermatitis (7,8) was weaker than that in the skin of healthy per sons. Psoriatic patients, by contrast, gave the same response as control subjects to intracutancously administered histamine (8).…”

Actions of locally administered adrenoceptor agonists on histamine-induced cutaneous responses in atopic eczema

“…Equally, the increased reactivity to alpha-adrenoceptor stimulation, inferred from in vitro studies (Szentivanyi et al, 1980), does not appear to have an in vivo counterpart in the cutaneous vessels of patients with atopic eczema. Decreased flare responses to intracutaneous histamine in atopic eczema have been previously reported (Eyster, Roth & Kierland, 1952;Michaelsson, 1970) and this phenomenon may be secondary to eczematous inflammation (Uehara, 1982).…”

Methacholine Chloride

“…6 If, as discussed pre¬ viously, norepinephrine is the cause of this vasoconstriction, adequate doses of reserpine should have a favorable effect on the course of the disease. Unfortunately, the amount of reserpine required to remove norepi¬ nephrine from the walls of cutaneous ar¬ teries is substantially more than is usually administered to human beings for therapeu¬ tic purposes.…”