Studies on the Ozyorsk population: health effects

Koshurnikova, N.A.; Mushkacheva, G.S.; Shilnikova, Natalia S.; Rabinovich, E.; Petrushkina, Nadezhda P.; Hall, Per; Bolotnikova, Marina G.; Preston, Dale L.; Ron, Elaine

doi:10.1007/s00411-001-0133-4

Cited by 13 publications

(7 citation statements)

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“…This registry, which is known as the Ozyorsk Offspring Cohort [referred to as the Mayak Children’s Cohort (18)], includes offspring of Mayak workers and other children meeting the above mentioned age and residential history criteria. For both the Ozyorsk Offspring Cohort and Mayak Worker Cohort, vital status follow-up and cause of death are actively ascertained using address bureau records and vital statistics data (including death certificates and autopsy reports) (18). …”

Section: Methodsmentioning

confidence: 99%

Cancer Mortality FollowingIn UteroExposure Among Offspring of Female Mayak Worker Cohort Members

et al. 2012

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Little is known about long-term cancer risks following in utero radiation exposure. We evaluated the association between in utero radiation exposure and risk of solid cancer and leukemia mortality among 8,000 offspring, born from 1948–1988, of female workers at the Mayak Nuclear Facility in Ozyorsk, Russia. Mother’s cumulative gamma radiation uterine dose during pregnancy served as a surrogate for fetal dose. We used Poisson regression methods to estimate relative risks (RRs) and 95% confidence intervals (CIs) of solid cancer and leukemia mortality associated with in utero radiation exposure and to quantify excess relative risks (ERRs) as a function of dose. Using currently available dosimetry information, 3,226 (40%) offspring were exposed in utero (mean dose = 54.5 mGy). Based on 75 deaths from solid cancers (28 exposed) and 12 (6 exposed) deaths from leukemia, in utero exposure status was not significantly associated with solid cancer: RR = 0.94, 95% CI 0.58 to 1.49; ERR/Gy = −0.1 (95% CI < −0.1 to 4.1), or leukemia mortality; RR = 1.65, 95% CI 0.52 to 5.27; ERR/Gy = −0.8 (95% CI < −0.8 to 46.9). These initial results provide no evidence that low-dose gamma in utero radiation exposure increases solid cancer or leukemia mortality risk, but the data are not inconsistent with such an increase. As the offspring cohort is relatively young, subsequent analyses based on larger case numbers are expected to provide more precise estimates of adult cancer mortality risk following in utero exposure to ionizing radiation.

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Section: Methodsmentioning

confidence: 99%

Cancer Mortality FollowingIn UteroExposure Among Offspring of Female Mayak Worker Cohort Members

et al. 2012

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“…No evidence of a decrease in birth rate or fertility in the exposed population nor increased incidence of spontaneous abortions or stillbirths has been observed (Kossenko et al, 1994). There has been one study (Koshurnikova et al, 2002) of persons living in the town of Ozyorsk exposed to fallout from the nearby nuclear facility. This study reported an excess of thyroid cancer 3-4 times than expected relative to rates for the whole of Russia and a somewhat lower excess (1.5-to 2-fold higher) based on a comparison with Chelyabinsk Oblast rates; however, no estimates of radiation dose were included in this study.…”

Section: Environmental Epidemiologymentioning

confidence: 96%

Radioactivity, Geochemistry, and Health

Siegel

Bryan

2014

Treatise on Geochemistry

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“…The companion manuscripts in this issue of Radiation and Environmental Biophysics [1,2,3,4,5,6] outline and discuss in detail the ongoing studies of cohorts that have been exposed to ionizing radiation in the former Soviet Union. The establishment of these cohorts was based on (a) the exposure due to the employment in the Mayak Production Association (MPA), i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Mayak workers cohort [1], (b) the exposure of the regional Ozyorsk population due to atmospheric releases of radionuclides from MPA, i.e. Ozyorsk population cohort [2], (c) the exposure due to accidental releases from the Mayak facility into the river Techa, resulting in exposed populations, i.e. Techa river cohort [3,4], and (d) the exposure to the fallout from nuclear tests that were conducted at the Semipalatinsk test site affecting Semipalatinsk and the Altai region [5,6].…”

Section: Introductionmentioning

confidence: 99%

Developing additional resources

Grosche

et al. 2002

Radiat Environ Biophys

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We briefly outline existing information about several cohorts in the Southern Urals, Semipalatinsk and the Altai regions, in addition to those discussed in the companion papers in this issue of Radiation and Environmental Biophysics. These include: (a) the East-Urals Radiation Trace (EURT) cohort of individuals (exposed to fallout from the September 1957 explosion of a storage tank containing liquid radioactive waste from the Mayak Production Association) as well as their offspring, (b) the cohort of exposed parents (i.e. workers of the Mayak facility) and their children, having been established with the aim of examining reproductive health, and (c) several additional cohorts in the Altai region and in Semipalatinsk, where investment of additional resources would greatly facilitate the progress of ongoing studies. Furthermore, we include a brief description of the Russian Human Radiobiology Tissue Repository, which has been established in the city of Ozyorsk and is in the process of making an inventory of autopsied tissues from 700 deceased Mayak workers and of collecting and storing donations of blood and tumor tissues from the members of the Mayak workers cohort currently residing in the city.

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Studies on the Ozyorsk population: health effects

Cited by 13 publications

References 1 publication

Cancer Mortality FollowingIn UteroExposure Among Offspring of Female Mayak Worker Cohort Members

Cancer Mortality FollowingIn UteroExposure Among Offspring of Female Mayak Worker Cohort Members

Radioactivity, Geochemistry, and Health

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