Studies on the oestrus‐producing hormone (oestrin)<sup>1</sup>

Hemmingsen, Axel M.

doi:10.1111/j.1748-1716.1933.tb00348.x

Cited by 66 publications

(21 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A hop covers the distance of approximately one extended body length (Madlafousek and Hliňák, 1977). Darting is a specialized form of a runaway from the male in which the female accelerates swiftly, using rapid low steps with the body held near the floor (Hemmingsen, 1933; Beach, 1942). The series of hopping-and-darting typically ends with a presentation behavior, or a pre-lordotic crouch (Madlafousek and Hliňák, 1977).…”

Section: Rodent Sexual Behaviorsmentioning

confidence: 99%

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Rudzinskas

Williams

Mong

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Methamphetamine (METH) is a psychomotor stimulant that is reported to enhance sexual desire and behavior in both men and women, leading to increases in unplanned pregnancies, sexually-transmitted infections, and even comorbid psychiatric conditions. Here, we discuss our rodent model of increased sexually-motivated behaviors in which the co-administration of METH and the ovarian hormones, estradiol and progesterone, intensify the incentive properties of a sexual stimulus and increases measures of sexually-motivated behavior in the presence of an androgen-specific cue. We then present the neurobiological mechanisms by which this heightened motivational salience is mediated by the actions of METH and ovarian hormones, particularly progestins, in the posterodorsal medial nucleus of the amygdala (MePD), a key integration site for sexually-relevant sensory information with generalized arousal. We finally demonstrate the cellular and molecular mechanisms underlying this facilitation of sexual motivation by METH, including the upregulation, increased phosphorylation, and activation of progestin receptors (PRs) in the MePD by METH in the presence of ovarian hormones. Taken together, this work extends our understanding of the neurobiology of female sexual motivation.

show abstract

Section: Rodent Sexual Behaviorsmentioning

confidence: 99%

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Rudzinskas

Williams

Mong

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Manual stimulation by an experimenter has long been used as a tool for determining the endocrine state of female rats (Adler & Bell, 1969;Ball, 1937;Blandau, Boling, & Young, 1941;Gerall & McGrady, 1970;Hemmingsen, 1933;Zucker, 1967). In the present article the somatosensory stimulation itself is the object of concern, for the purpose of guiding studies in the sensory physiology of lordosis.…”

mentioning

confidence: 97%

Somatosensory determinants of lordosis in female rats: Behavioral definition of the estrogen effect.

Pfaff¹,

Montgomery²,

Lewis³

1977

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

By coating the ventral surface of male rats with a dye, regions of contact between male and female during male mounting were recorded precisely on the female's hair and skin. The male rat touches the female's flanks, rump, tailbase, perineum, and perivaginal surfaces during the female's initiation and maintenance of lordosis. Film analyses showed that the male's paws and pelvic thrusting stimulate the female's skin with dominant frequencies between 10 and 20 per second. Somatosensory stimuli were applied by the experimenter to the female skin locations contacted by the male. Deflection of hair on the flanks or perineum alone did not cause lordosis. Light stimulation simultaneously on flanks and perineum caused lordosis only in some females given high estrogen dosages supplemented by progesterone. When flank stimuli were followed by pressure on the rump, tailbase, and perineum, lordosis was triggered reliably in hormone-treated females. Here the estrogen-dependence of the reflex was shown, and progesterone synergized with the estrogen effect. Among lordosis components, rump and head elevations in response to pressure stimuli on the rump, tailbase, and perineum appear to be hormone-sensitive. These results help to define the minimal cutaneous sensory requirement for lordosis. In turn, the estrogen effect on lordosis may be defined behaviorally as increased responsiveness to pressure on rump, tailbase, and perineal skin, after flank stimulation. The results illustrate how estrogen, progesterone, and Somatosensory stimuli interact in causing lordosis, increases in the strength of one factor compensating for decreases in another.Precise descriptions of sensory and mo-initiation of lordosis . tor aspects of reproductive behavior faciliSurgical cutaneous denervation or subcutate its neurophysiological analysis and, taneous injections of procaine in the postein turn, the analysis of hormone effects, rior rump, tailbase, perineal and flank reDetailed observations of lordosis responses gions of the female rat produced signifiby female rats, following mounts by male cant decrements in lordosis. What somatorats in filmed mating encounters, have sensory stimuli are sufficient for triggershown the occurrence and timing of move-ing lordosis in the female rat? Since the ments by the female and male (Pfaff & male rat applies natural stimuli as a con- Lewis, 1974). Experiments involving the stellation, observation of his behavior, surgical elimination of entire sensory mod-alone, is not analytical enough to show the alities or of specific forms of Somatosensory minimal sufficient stimulation. Rather, stimulation have shown which stimuli imitations of the stimuli he applies must provided by the male are essential for the be given separately and in combination

show abstract

“…Sofort sie ein solches agnosieren, verfolgen sie es unaufhorlich, umverben es leidenschaftlich und springen auf ' (p. 327). Similarly, early studies showed that female sexual behavior could be induced in ovariectomized rats by estrogen treatment (Allen, Francis, Robertson, Colgate, Johston, Doisy, Kounts & Gibson, 1924;Hemmingsen, 1933;Hemmingsen & Krarup, 1937) and evidence was presented that ovarian transplants or estrogen treatment also produced part of the feminine behavior in castrated male rats (Ball, 1939; Sodersten, 1975. ) 1912; Kun, 1934).…”

Section: Early Studies On the Activation Of Sexual Behavior In Males mentioning

confidence: 95%

Theoretical considerations of the differentiation of sexual behavior: Evidence from animal experiments

Södersten

Hansen

1980

Scandinavian J Psychology

View full text Add to dashboard Cite

Some aspects of the experimental study of hormonally controlled sexually dimorphic behavior patterns are discussed, using results derived from research on rat and guinea pig sexual behavior as the model. The traditional concept that sex differences in behavior are due to differences in hormone sensitivity may be only partially correct and it is suggested that the sexes differ primarily in the extent to which their behavior is influenced by diurnal rhythm mechanisms.

show abstract

Studies on the oestrus‐producing hormone (oestrin)¹

Cited by 66 publications

References 78 publications

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Somatosensory determinants of lordosis in female rats: Behavioral definition of the estrogen effect.

Theoretical considerations of the differentiation of sexual behavior: Evidence from animal experiments

Contact Info

Product

Resources

About

Studies on the oestrus‐producing hormone (oestrin)1

Cited by 66 publications

References 78 publications

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

Somatosensory determinants of lordosis in female rats: Behavioral definition of the estrogen effect.

Theoretical considerations of the differentiation of sexual behavior: Evidence from animal experiments

Contact Info

Product

Resources

About

Studies on the oestrus‐producing hormone (oestrin)¹