STUDIES ON THE NUTRITION AND PHYSIOLOGY OF
            <i>PASTEURELLA PESTIS</i>

Higuchi, Kiyoshi; Kupferberg, L. L.; Smith, James L.

doi:10.1128/jb.77.3.317-321.1959

Cited by 101 publications

(1 citation statement)

References 7 publications

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“…Growth rates for the utilization of a substrate as a carbon and energy source was determined in modified TMH, with gluconate removed as a carbon and energy source [28]. To require greater stringency on single carbon source utilization, the media was additionally modified to remove non-essential amino acids.…”

Section: Determination Of Growth Ratesmentioning

confidence: 99%

Correction: Transcriptome Analysis of Acetyl-Homoserine Lactone-Based Quorum Sensing Regulation in Yersinia pestis

LaRock¹,

Horswill²,

Parsek³

et al. 2013

PLoS ONE

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The etiologic agent of bubonic plague, Yersinia pestis, senses self-produced, secreted chemical signals in a process named quorum sensing. Though the closely related enteric pathogen Y. pseudotuberculosis uses quorum sensing system to regulate motility, the role of quorum sensing in Y. pestis has been unclear. In this study we performed transcriptional profiling experiments to identify Y. pestis quorum sensing regulated functions. Our analysis revealed that acyl-homoserine lactonebased quorum sensing controls the expression of several metabolic functions. Maltose fermentation and the glyoxylate bypass are induced by acyl-homoserine lactone signaling. This effect was observed at 30uC, indicating a potential role for quorum sensing regulation of metabolism at temperatures below the normal mammalian temperature. It is proposed that utilization of alternative carbon sources may enhance growth and/or survival during prolonged periods in natural habitats with limited nutrient sources, contributing to maintenance of plague in nature.

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Section: Determination Of Growth Ratesmentioning

confidence: 99%