Studies on the Morphology of the Adrenal Cortex and on the Excretion of 17-Ketosteroids in Hypertensive Patients

Bruger, Maurice; Rosenkrantz, J. A.; Lowenstein, Bertand E.

doi:10.1097/00000441-194408000-00011

Cited by 18 publications

(4 citation statements)

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“…Preliminary data from this laboratory suggest that there is little correlation between presence of adrenal cortical adenomatous hyperplasia and level of blood pressure in the dog. Bruger et al (24) have analyzed the incidence of adrenal cortical hyperplasia and benign adenomatosis in hypertensive as contrasted with normotensive patients. No differences were found.…”

Section: Discussionmentioning

confidence: 99%

Serial Renal Clearances in Dogs With Nephrogenic and Spontaneous Hypertension

Stamler¹,

Katz²,

Rodbard³

1949

Journal of Experimental Medicine

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The production of experimental hypertension by the Goldblatt mechanism of partial constriction of the renal arteries has been interpreted as due to renal "ischemia." However, renal blood flow studies have made it apparent that, at least during the early stages of experimental hypertension, the renal blood flow may be quantitatively within normal limits. The sequential changes in renal blood flow with prolonged experimental nephrogenic hypertension due to constriction of the renal arteries have not been studied. These were investigated in order to establish whether prolonged constriction of the renal arteries produces long standing hemodynamic and pathologic changes.In the course of this study, analyses were also undertaken on dogs considered to have "spontaneous" hypertension. After an extended period of training for blood pressure determinations, occasional dogs were observed in which the pressure remained at what is considered to be hypertensive levels. Instead of a pressure level of 155/80 nun. Hg,' these animals had persistent pressures in excess of 185/100 even though they were at rest, well trained, and without visible excitement. These animals were considered of particular interest because of the possibility that they may have other characteristics similar to those observed in human essential hypertension.Furthermore, the occurrence of such spontaneous hypertension in the dog may afford an opportunity to study the effect of an increased arterial pressure on the renal arterioles and parenchyma, in contrast to the hypertension produced by the Goldblatt technique. In the latter case, the presence of the renal artery clamp or ligature may prevent the full action of the arterial hypertension upon the kidney.

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Section: Discussionmentioning

confidence: 99%

Serial Renal Clearances in Dogs With Nephrogenic and Spontaneous Hypertension

Stamler¹,

Katz²,

Rodbard³

1949

Journal of Experimental Medicine

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“…The majority of incidentally discovered adrenal masses are nonhyperfunctioning benign adrenal adenomas, representing 36‐94% of all adrenal masses in patients without a known malignancy ( Abecassis et al ., 1985 , Prinz et al ., 1982 , Mitnick et al ., 1983 ; Guerrero, 1985; Bitter & Ross, 1989; Hubbard et al ., 1989 ; Siren et al ., 1993 ). The reported prevalence of adrenal adenomas at autopsy varies widely, but is as high as 68% ( Bruger et al ., 1944 ; Shamman et al ., 1958 ).…”

Section: Biochemical Investigationmentioning

confidence: 99%

Imaging of incidentally discovered adrenal masses

Peppercorn

Grossman

Reznek

1998

Clinical Endocrinology

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“…It is thought that in women the urinary 17-ketosteroids are derived from the adrenals only, and that the ovaries probably play no part in their production, since \l=o"\ophorectomy does not significantly alter the excretion [assays have been reported in women suffering from Addison's disease [Fraser et al 1941]. Accordingly two female patients undergoing surgical treatment for essential hypertension were selected for this investigation.Low excretions have been reported in some hypertensive patients by Bruger, Rosenkrantz & Lowenstein [1944] and Selye [1947], but as Talbot & Butler [1942] and other workers have shown, there is a tendency in chronic illness from any cause for the 17-ketosteroid excretion to be moderately low.Forbes, Donaldson, Reifenstein & Albright [1947] found that in relatively healthy patients various types of acute trauma (e.g. operations, burns, acute infections) resulted in a definite pattern of 17-ketosteroid excretion.…”

mentioning

confidence: 94%

“…Low excretions have been reported in some hypertensive patients by Bruger, Rosenkrantz & Lowenstein [1944] and Selye [1947], but as Talbot & Butler [1942] and other workers have shown, there is a tendency in chronic illness from any cause for the 17-ketosteroid excretion to be moderately low.…”

mentioning

confidence: 94%

The Excretion of Urinary Neutral 17-Ketosteroids Following Bilateral Splanchnicectomy and Right Adrenalectomy

Michie¹,

Clayton²

1950

Journal of Endocrinology

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The aim of the present study has been to discover whether the total urinary excretion of neutral 17-ketosteroids is affected by division of the nerves supplying the adrenal glands, with or without complete removal of one adrenal gland.During treatment for essential hypertension, selected patients undergo bilateral splanchnicectomy resulting in complete section of the nerve supply of the adrenal glands, and in addition right-sided adrenalectomy may be performed. It is thought that in women the urinary 17-ketosteroids are derived from the adrenals only, and that the ovaries probably play no part in their production, since \l=o"\ophorectomy does not significantly alter the excretion [assays have been reported in women suffering from Addison's disease [Fraser et al. 1941].Accordingly two female patients undergoing surgical treatment for essential hypertension were selected for this investigation.Low excretions have been reported in some hypertensive patients by Bruger, Rosenkrantz & Lowenstein [1944] and Selye [1947], but as Talbot & Butler [1942] and other workers have shown, there is a tendency in chronic illness from any cause for the 17-ketosteroid excretion to be moderately low.Forbes, Donaldson, Reifenstein & Albright [1947] found that in relatively healthy patients various types of acute trauma (e.g. operations, burns, acute infections) resulted in a definite pattern of 17-ketosteroid excretion. Within 24-48 hr. of operation there was an increase in excretion to a higher level than normal followed by a rapid fall to a low level on the fourth or fifth day, with a return to normal levels in 10 days. The peak which preceded the fall tended to be more marked in men than in women. When the patients were chronically ill or debilitated the response to trauma was only slight or absent altogether. Their patients included three men who had had bilateral lumbodorsal splanchnicectomy performed in two stages for essential hypertension, and their 17-ketosteroid excretion followed the typical pattern with an eventual return to pre-operative levels. In view of these findings, the period between the two operations in our patients for this investigation was greater than 10 days, and excretion after the second operation was observed for longer than 10 days in order to be certain that the post-operative phase was over.

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Studies on the Morphology of the Adrenal Cortex and on the Excretion of 17-Ketosteroids in Hypertensive Patients

Cited by 18 publications

References 0 publications

Serial Renal Clearances in Dogs With Nephrogenic and Spontaneous Hypertension

Serial Renal Clearances in Dogs With Nephrogenic and Spontaneous Hypertension

Imaging of incidentally discovered adrenal masses

The Excretion of Urinary Neutral 17-Ketosteroids Following Bilateral Splanchnicectomy and Right Adrenalectomy

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