Studies on the Modification of Radiation Injury

Jacobson, Leon O.; Marks, Edna K.; Gaston, E. O.; Simmons, Eric L.

doi:10.1002/9780470718902.ch14

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…These findings supplement those of Lorenz( 1,2), Jacobson and his associates (3,4), and Cole et d ( 6 ) which show the efficacy of heterologous tissue (rat to mouse, guinea pig to mouse) in prolonging the survival of irradiated mice. The data from this investigation indicate that cells from the embryonic mouse liver or from baby mouse liver or spleen are capable of enhancing the survival of rabbits exposed to 900 r total-body X radiation.…”

Section: Results Survival As Indicated Insupporting

confidence: 84%

“…Heterdogous tissue transplants or cell suspensions of hematopoietic origin have been reported by Lorenz and h,is associates ( 1,2) and Jacobson et a L ( 3 ) to have a significanlt effect on survival and hematopoietic regeneration of irradiated rodents. Jacobson first described evidence that suggested the effectiveness of mouse spleen transplants for has-tening recovery of the bld-forming tissue of irradiated rabbits (4).…”

mentioning

confidence: 94%

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Modification of Radiation Injury in the Rabbit

Jacobson¹,

Marks²,

Gaston³

1956

Experimental Biology and Medicine

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Section: Results Survival As Indicated Insupporting

confidence: 84%

mentioning

confidence: 94%

Modification of Radiation Injury in the Rabbit

Jacobson¹,

Marks²,

Gaston³

1956

Experimental Biology and Medicine

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“…It has long been suggested that hematopoietic recovery is dependent upon the regeneration of the BM vasculature (90, 91). Utilizing in vivo genetic models, Heissig et.…”

Section: Essential Role Of the Endothelial Niche In Hematopoietic Regmentioning

confidence: 99%

Regulation of the hematopoietic stem cell lifecycle by the endothelial niche

Ramalingam¹,

Poulos²,

Butler³

2017

Current Opinion in Hematology

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Purpose of review Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a vast repertoire of biological processes crucial for HSC maintenance throughout its lifespan. In this review, we will discuss recent findings in endothelial niche-mediated regulation of HSC function during development, aging and regenerative conditions. Recent findings Studies employing genetic vascular models have unequivocally confirmed that ECs provide the essential instructive cues for HSC emergence during embryonic development as well as adult HSC maintenance during homeostasis and regeneration. Aging of ECs may impair their ability to maintain HSC function contributing to the development of aging-associated hematopoietic deficiencies. These findings have opened up new avenues to explore the therapeutic application of ECs. ECs can be adapted to serve as an instructive platform to expand bona fide HSCs and also utilized as a cellular therapy to promote regeneration of the hematopoietic system following myelosuppressive and myeloablative injuries. Summary ECs provide a fertile niche for maintenance of functional HSCs throughout their lifecycle. An improved understanding of the EC-HSC cross-talk will pave the way for development of EC-directed strategies for improving HSC function during aging.

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Problems of Radiation Protection from the Diagnostic Radiologist's Viewpoint

Hooper

1958

Australas Radiol

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Studies on the Modification of Radiation Injury

Cited by 3 publications

References 24 publications

Modification of Radiation Injury in the Rabbit

Modification of Radiation Injury in the Rabbit

Regulation of the hematopoietic stem cell lifecycle by the endothelial niche

Problems of Radiation Protection from the Diagnostic Radiologist's Viewpoint

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