Studies on the mode of action of isosorbide dinitrate: A physiologic and biochemical approach

Matlib, Mohammed A.; Dubé, Gregory P.; Millard, Ronald W.; Lathrop, David A.; Baik, Yung Hong; Sakai, Kazushige; DiSalvo, Joseph; Schwartz, Arnold

doi:10.1016/0002-8703(85)90488-0

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Our findings are similar to those recently reported by Matlib et al (1985) using a similar experimental protocol but studying the effects of isosorbide dinitrate on bovine coronary artery preparations.…”

Section: Discussionsupporting

confidence: 92%

“…Possible mechanisms for reducing cytosolic calcium would be inhibition of calcium influx through one or other of its membrane 'channels' or reduction of intracellular calcium release ). The influence of nitrovasodilators on calcium fluxes has been the subject of a number of studies (Haeusler & Thorens, 1975;Kreye, Baron, Lfith & Schmidt-Gayk, 1975;Zsoter, Henein & Wolchinsky, 1977;Hester, Weiss & Fry, 1979;Karaki, Hester & Weiss, 1980;Nakazawa & Imai, 1981;Ozaki, Shibata, Kitano, Matsumoto & Ishida, 1981;Itoh, Kuriyama & Ueno, 1983;Karaki, Nakagawa & Urakawa, 1984;Hester, 1985;Matlib, Dube, Millard, Lathrop, Baik, Sakai, Disalvo & Schwartz, 1985) with conflicting findings related possibly to differences in methodology and between different species studied. The influence of EDRF on calcium fluxes has not been studied previously.…”

Section: Introductionmentioning

confidence: 99%

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Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.

Collins¹,

Griffith²,

Henderson³

et al. 1986

The Journal of Physiology

126

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SUMMARY1. Measurement of tension and 45Ca influx and efflux were used to study the effects of endothelium-derived relaxing factor (EDRF), sodium nitroprusside and 8-bromocyclic guanosine monophosphate (GMP) on contractile responses and calcium movements in aortic ring preparations of the rabbit.2. EDRF activity, induced by stimulating endothelium-containing rings with acetylcholine, was associated with relaxation of noradrenaline-constricted rings and with a marked reduction of noradrenaline-stimulated increase in calcium influx.Sodium nitroprusside and 8-bromo-cyclic GMP had a similar effect in deendothelialized preparations.3. EDRF also inhibited noradrenaline-stimulated calcium efflux. Sodium nitroprusside and 8-bromo-cyclic GMP had a similar effect in de-endothelialized preparations, both in the presence and absence of extracellular calcium.4. The vascular smooth muscle relaxant effect of EDRF and of nitrovasodilators may be effected by a cyclic GMP-mediated reduction of cytosolic calcium, through both inhibition of calcium influx and reduction of intracellular calcium release.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.

Collins¹,

Griffith²,

Henderson³

et al. 1986

The Journal of Physiology

126

View full text Add to dashboard Cite

show abstract

“…31 Furthermore, it has been reported that a nitric oxide donor, such as isosorbide dinitrate, increases the diameter of large coronary arteries without affecting coronary blood flow at low doses and increases both coronary diameter and blood flow at higher doses. 32 The increase in coronary flow by nicorandil was inhibited by the 5-HD but the curve tended to be situated at higher position in the nicorandil +5-HD group than in the control group, although not significant statistically as shown in Fig 5. This suggests that this difference might be a result of the nitrate action of nicorandil.…”

Section: Discussionmentioning

confidence: 74%

Nicorandil Improves Post-Ischemic Myocardial Dysfunction in Association With Opening the Mitochondrial K<sub>ATP</sub> Channels and Decreasing Hydroxyl Radicals in Isolated Rat Hearts

Minatoguchi

Arai

et al. 2006

Circ J

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“…A decrease in circulating blood volume results in dilation of the systemic vascular pre-load to the heart to relieve volume overload. The second reason can be the improvement of coronary circulation [1,25]. Nitrates have a cardioprotection effect in maintaining the coronary circulation volume through dilation of coronary vascular.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Volume Overload Heart

Shimamura

OHSAWA

Kobayashi

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Recently, it has been reported that intermittent administration of nitrate, with a nitrate-free interval of 10 to 12 hr eliminated expression of tolerance, and maintained its hypotensive effect. In the present study, we evaluated whether nitrate tolerance developed or not with an intermittent administration of sr-ISDN (5 mg/kg/ once a day) in Wistar rats. The effect of this administration protocol for sr-ISDN on the volume overload heart model, aortovenous fistula, was also examined. Furthermore, blood pressure was monitored by radio telemetry during sr-ISDN (5 mg/kg/once a day) administration. Nitrate tolerance did not develop, and eccentric hypertrophy due to volume overload was moderated by sr-ISDN administration. Sr-ISDN administration maintained blood pressure lower level than the placebo group. In conclusion, prolonged intermittent administration of sr-ISDN maintained its hypotensive effect during the entire experiment period, without developing tolerance, and moderated efferent hypertrophy with attenuated volume overload. KEY WORDS: aortovenous fistura, isosorbide dinitrate, rat, volume overload.

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Studies on the mode of action of isosorbide dinitrate: A physiologic and biochemical approach

Cited by 11 publications

References 14 publications

Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.

Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.

Nicorandil Improves Post-Ischemic Myocardial Dysfunction in Association With Opening the Mitochondrial K<sub>ATP</sub> Channels and Decreasing Hydroxyl Radicals in Isolated Rat Hearts

The Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Volume Overload Heart

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