Studies on the Mode of Action of Sodium Pentobarbital in Blocking Ovulation in Rats

Zolovick, A.J.; Labhsetwar, A. P.

doi:10.1530/jrf.0.0420199

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“…This suggestion is further supported by the fact that Nembutal, when applied locally in the median eminence, can inhibit ovulation, while application to the anterior pituitary has no effect (Zolovick & Labhsetwar, 1975). However, the manner in which Nembutal affects the mechanisms of neural protein synthesis is not understood.…”

Section: Discussionmentioning

confidence: 99%

“…Apparently Nembutal does not have a direct effect on the ovary in preventing its response to a delayed rise in LH (Zolovick & Labhsetwar, 1975). Nevertheless, since there is evidence to suggest that the integrity of neural connexions to the ovary is required for normal ovula¬ tory processes (see Hill, 1949;Bahr, Kao & Nalbandov, 1974) an effect of Nembutal on ovarian innervation remains a possibility.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Sodium Pentobarbitone on Serum Gonadotrophin Levels and on the Incorporation of 35s From Methionine Into Protein in the Brain and Anterior Pituitary During the Oestrous Cycle of the Rat

Haar¹,

Mackinnon²

1976

Journal of Endocrinology

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Ovulation was delayed for 24 h after the administration of sodium pentobarbitone (Nembutal, 35 mg/kg body weight) at 14.00 h, before the critical period on the afternoon of pro-oestrus. The expected preovulatory surge of serum LH at 18.00 h of pro-oestrus was also delayed until 21.00 h on the following day; however, increased levels (less than 12 ng/ml) were observed in 14 out of 23 animals (killed by decapitation) at 21.00 h on the day of Nembutal administration. The serum FSH rise observed on the morning of expected oestrus was extended after Nembutal treatment, and a further rise was noted 24 h later. Peak levels of incorporation of 35S from methionine into protein of the median eminence area (ME) and of the anterior pituitary (AP) which normally occur about the time of the preovulatory LH surge, were also delayed until 21.00 h on the day following Nembutal administration. Neither ovulation nor the preovulatory gonadotropin rises with their accompanying changes in incorporation in the ME and the AP, were altered by Nembutal administered after the pro-oestrous critical period. Thus Nembutal, while blocking ovulation, inhibits the circadian rhythm of incorporation of 35S from methionine in the brain as well as the peaks of incorporation in the median eminence and the anterior pituitary which accompany the normal preovulatory surges of gonadotrophin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%