Studies on the Metabolic Fate of L-Carnosine in Rats and Humans.

Furuta, Shigeru; Toyama, Seiji; Miwa, Masahiro; Sano, Hiroshi

doi:10.2133/dmpk.8.1057

Cited by 4 publications

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“…Moreover, the t 1/2 of anserine in blood was remarkably shorter than the t 1/2 of π-methylhistidine. These results suggest that intact anserine is absorbed across the human gastrointestinal tract and is sequentially hydrolyzed to π-methylhistidine and β-alanine by serum and tissue carnosinases in a manner similar to that for carnosine .…”

Section: Resultsmentioning

confidence: 82%

“…Gardner performed a recovery study of carnosine added in vitro to plasma at either 4 or 37 °C, suggesting that plasma carnosinase hydrolyzed the added carnosine (200 nmol/mL) with a half-life of the order of 1 min at 37 °C. Furuta et al incubated [ 14 C]-carnosine added to human plasma at room temperature. They found that the total amount of [ 14 C]-carnosine decomposed β-alanine and [ 14 C]-histidine within 15 min.…”

Section: Resultsmentioning

confidence: 99%

“…This result possibly emerged from the difference in utilization by the human body. Half the L-histidine was further utilized for incorporation of endogenous high molecular weight substances (19), whereas π-methylhistidine, after the ingestion of anserine, was excreted without being metabolized (14, 22). This is also why no increase in L-histidine was detected in subjects administered anserine alone in this study.…”

Section: Resultsmentioning

confidence: 99%

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Intestinal Absorption and Blood Clearance of l-Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

Kubomura

Matahira

Masui

et al. 2009

J. Agric. Food Chem.

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Anserine is a bioactive dipeptide found in muscles and brains of vertebrates, but little is known about the kinetics of its absorption into blood and the clearance after the ingestion of anserine or anserine-containing diets. This study investigated time-dependent changes in the concentrations of l-histidine-related compounds from deproteinized blood. The concentration of anserine peaked and then decreased to zero, whereas the concentration of pi-methylhistidine gradually increased, at which point anserine was not detected. Thus, ingested anserine is absorbed intact in human blood and is hydrolyzed to pi-methylhistidine and beta-alanine by serum and tissue carnosinases. Moreover, the crossover study suggests that there was no significant difference in absorption under curves of anserine between anserine alone and anserine-containing diet, whereas there was significant difference in the peak concentration of anserine. This is the first study to demonstrate intestinal absorption and blood clearance of anserine.

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Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Intestinal Absorption and Blood Clearance of l-Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

Kubomura

Matahira

Masui

et al. 2009

J. Agric. Food Chem.

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“…However, liver cancer cells express both carnosinase 1 and carnosinase 2 but at lower levels when compared with normal liver and human plasma . Furuta et al reported a complete conversion of l ‐carnosine to l ‐histidine within 15 minutes in vitro in the presence of human plasma, and Gardner et al reported carnosine half‐life of the order of 1 minute in ex vivo human serum . Thus, significant accumulation of carnosine in the in vitro assay may be unlikely due to the short half‐life of carnosine.…”

Section: Discussionmentioning

confidence: 99%

Carnosine exhibits significant antiviral activity against Dengue and Zika virus

Rothan

Abdulrahman

Khazali

et al. 2019

Journal of Peptide Science

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“…After administration of 14C-, 65Zn-polaprezinc, plasma concentrations of 65Zn-radioactivities were different from 14C-radioactivities. This finding indicated that polaprezinc is dissociated to zinc and L-carnosine on administration, and zinc is metabolized along with the metabolic turnover of the endogenous zinc, while L-carnosine is metabolized and utilized in the synthesis of endogenous high molecular weight substances such as proteins (15,25,26).…”

Section: Discussionmentioning

confidence: 99%

Residence Time of Polaprezinc (Zinc L-Carnosine Complex) in the Rat Stomach and Adhesiveness to Ulcerous Sites

Furuta

Toyama

Miwa

et al. 1995

Japanese Journal of Pharmacology

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ABSTRACT-Polaprezinc, an insoluble zinc complex of L-carnosine, exhibits anti-ulcer effects by acting directly on mucosal lesions. The disposition of polaprezinc in the stomach was studied to clarify the usefulness of its structure as an insoluble complex. The time courses of 14C-radioactivity in the gastric contents and gastric tissues were parallel to those of 65Zn after oral administration of a mixture of 14C-polaprezinc and 65Zn-polaprezinc (14C-, 65Zn-polaprezinc) to rats. The gastric contents of '4C-polaprezinc and 65Zn-polaprezinc were greater than those of 14C-L-carnosine and 65ZnSO4. Mean residence times (MRT) of 14C-polaprezinc and 65Zn-polaprezinc in the stomach were almost the same (ca. 2 hr), and they were double those of 14C-L-carnosine and 65ZnSO4. In gastric tissues, the area under the concentration curves (AUCO_8 hr) of 14C-polaprezinc and 65Zn-polaprezinc were 1.7 times greater than those of '4C-L-carnosine and 65ZnSO4i respectively. After administration of 14C-, 65Zn-polaprezinc to rats with acetic acid-induced ulcers, 14C and 65Zn-radioactivities in the ulcerous sites were very similar and greater than those of '4C-, 65Zn -polaprezinc dissolved in acid. In conclusion, polaprezinc is retained in the stomach longer and adheres to the ulcerous sites more than zinc or L-carnosine. The characteristics of this compound may arise from its insolubility and contribute to its strong pharmacological action.

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Studies on the Metabolic Fate of L-Carnosine in Rats and Humans.

Cited by 4 publications

References 0 publications

Intestinal Absorption and Blood Clearance of l-Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

Intestinal Absorption and Blood Clearance of l-Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

Carnosine exhibits significant antiviral activity against Dengue and Zika virus

Residence Time of Polaprezinc (Zinc L-Carnosine Complex) in the Rat Stomach and Adhesiveness to Ulcerous Sites

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