Studies on the Mechanisms of the Immune Reaction following the Transtracheo-bronchial Inoculation of Antigens

Abstract

The mechanisms of immune reaction were studied by observations of antigen transition, antibody producing cells, antibody titers and factors affecting them following the transtracheobronchial inoculation of antigens. Results were obtained as follow: Using immuno fluorescence method, intake of labeled antigen was confirmed in alveolar wall and also antibody containing cells were observed.Higher antibody titers and higher IgA levels were confirmed in serum and washing fluid of airway by the transtracheo-bronchial inoculation of antigen than by subcutaneous injection. Additionally, similar studies were performed following the exposure to irritant gases and subcutaneous injection of the immuno-suppressive drugs and some effects were revealed on antibody titers, IgA levels and antibody containing cells.