Studies on the mechanism of action of 6-mercaptopurine. Interaction with copper and xanthine oxidase

Kela, U; Vijayvargiya, R

doi:10.1042/bj1930799

Cited by 40 publications

(11 citation statements)

References 15 publications

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“…Some 6-MP is converted to nucleotide derivatives of 6-thioguanine (6TG) by the sequential actions of inosinate dehydrogenase and xanthylate aminase, converting thioinosinic acid to thioguanylic acid. Preclinical tumors resistant to 6-MP often cannot convert 6-MP to thioinosinic acid (26,27). However, many mechanisms of resistance to 6-MP have been identified, particularly in human leukemias (28).…”

Section: Introductionmentioning

confidence: 99%

Analyses of the combination of 6-MP and dasatinib in cell culture

Kaur

Behrsing

Parchment

et al. 2013

International Journal of Oncology

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A major tenet of cancer therapeutics is that combinations of anticancer agents with different mechanisms of action and different toxicities may be effective treatment regimens. Evaluation of additivity/synergy in cell culture may be used to identify drug combination opportunities and to assess risk of additive/synergistic toxicity. The combination of 6-mercaptopurine and dasatinib was assessed for additivity/synergy using the combination index (CI) method and a response surface method in six human tumor cell lines including MCF-7 and MDA-MB-468 breast cancer, NCI-H23 and NCI-H460 non-small cell lung cancer, and A498 and 786-O renal cell cancer, based on two experimental end-points: ATP content and colony formation. Clonal colony formation by human bone marrow CFU-GM was used to assess risk of enhanced toxicity. The concentration ranges tested for each drug were selected to encompass the clinical Cmax concentrations. The combination regimens were found to be additive to sub-additive by both methods of data analysis, but synergy was not detected. The non-small cell lung cancer cell lines were the most responsive among the tumor lines tested and the renal cell carcinoma lines were the least responsive. The bone marrows CFU-GM were more sensitive to the combination regimens than were the tumor cell lines. Based upon these data, it appears that the possibility of enhanced efficacy from combining 6-mercaptopurine (6-MP) and dasatinib would be associated with increased risk of severe bone marrow toxicity, so the combination is unlikely to provide a therapeutic advantage for treating solid tumor patients where adequate bone marrow function must be preserved.

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Section: Introductionmentioning

confidence: 99%

Analyses of the combination of 6-MP and dasatinib in cell culture

Kaur

Behrsing

Parchment

et al. 2013

International Journal of Oncology

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“…Their physiological functions are partly related to their interaction with metal ions [1,2]. Therefore, it is of special importance to investigate their electrochemical behavior on metal electrodes.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical study of a cetylpyridinium bromide/glutathione mixed membrane electrochemically deposited at polycrystalline Ag electrodes

Zeng

Huang

Zhao

et al. 2005

Journal of Electroanalytical Chemistry

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“…It was found that their physiological roles are partly related to the oxidation-reduction of -SH and -S-Sgroups, as well as the interaction of -SH/-S-S-with metal ions [4][5][6][7]. Most of these compounds exhibit electroactivity.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Behavior of 2-Mercaptopyrimidine at a Silver Electrode

Zeng

Purdy

1998

Electroanalysis

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Electrochemical characteristics of 2-mercaptopyrimidine (MPD) have been studied by linear scan voltammetry at a silver disk electrode (AgE). It was found that at appropriate potentials MPD can adsorb on and interact with the electrode to form an insoluble silver salt on the surface. As the potential is made more negative two cathodic peaks appear at ¹0.66 V and ¹1.28 V, respectively. The peak at ¹0.66 V is attributed to the reduction of the sparingly soluble silver compound of MPD, and the other to the reduction of MPD to pyrimidine, which was confirmed by capillary electrophoresis. The deposition/stripping behavior of MPD is discussed and possible mechanisms are proposed. Additionally, the influence of some surfactants and halides on the shape and height of the stripping peaks was determined. It was observed that cationic surfactants such as cetylpyridinium bromide and hexadecyltrimethylammonium bromide can dramatically increase the peak height and decrease the peak width of the peak at ¹0.66 V.

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Studies on the mechanism of action of 6-mercaptopurine. Interaction with copper and xanthine oxidase

Cited by 40 publications

References 15 publications

Analyses of the combination of 6-MP and dasatinib in cell culture

Analyses of the combination of 6-MP and dasatinib in cell culture

Electrochemical study of a cetylpyridinium bromide/glutathione mixed membrane electrochemically deposited at polycrystalline Ag electrodes

Voltammetric Behavior of 2-Mercaptopyrimidine at a Silver Electrode

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