Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome.

Jordan, Jay L.; Yamaguchi, Iwao; Mandel, William J.

doi:10.1161/01.cir.57.2.217

Cited by 156 publications

(37 citation statements)

References 65 publications

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“…The sensitivity of IHRp is very low for diagnosing sinus node dysfunction. Initially the same dosages were used for distinguishing between intrinsic and extrinsic sinus node dysfunction when assessing sinus node recovery time [164,165] , and later modified to 75% by Tonkin et al [166] . From a diagnostic point of view it seems sufficient to use propranolol 0·1 mg .…”

Section: Task Force Report 1273mentioning

confidence: 99%

Guidelines on management (diagnosis and treatment) of syncope

Brignole¹,

Alboni²,

Benditt

et al. 2001

European Heart Journal

678

432

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Section: Task Force Report 1273mentioning

confidence: 99%

Guidelines on management (diagnosis and treatment) of syncope

Brignole¹,

Alboni²,

Benditt

et al. 2001

European Heart Journal

678

432

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“…RECENT interest in sinus node function in man has led to an increasing awareness of the importance of vagal tone as a factor that modulates the degree of disturbance of nodal function (Dighton, 1974(Dighton, , 1975Jordan et al, 1978). The arrhythmias resulting from such a disturbance of nodal function include sinus bradycardia, sinus pause or arrest, and sinoatrial exit block.…”

mentioning

confidence: 99%

An analysis of the effects of acetylcholine on conduction and refractoriness in the rabbit sinus node.

Prystowsky¹,

Grant²,

Wallace³

et al. 1979

Circulation Research

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SUMMARY The effects of acetylcholine (ACh) on sinus node automaticity, atrio-sinus conduction, and refractoriness were studied in 41 isolated rabbit right atrial preparations. Average control rate was 126 beats/min, and ACh 5 x 10~8 M, 5 x 10"' M, and 5 x 10"' M significantly decreased heart rate by 7, 15, and 43%, respectively (P < 0.01, 0.001, and 0.001). Atrio-sinus conduction time at a pacing cycle length of 400 msec did not significantly change during exposure to ACh 5 x 10" 8 and 5 x 10~7 M. However, the mean effective refractory period (ERP) of the sinus node, at a pacing cycle length of 400 msec, increased from 183 ± 16 msec to 210 ± 24 msec during exposure to ACh 5 x 10"' M (P< 0.025). The change in ERP followed the change in action potential duration. In contrast to the lack of effect of ACh 5 x 10" 7 M on atrio-sinus conduction time, ACh 5 x 10~6 M caused 2:1 atrio-sinus block in 8 of 10 experiments. The site of block was identified using multiple microelectrode impalements, and occurred between the perinodal fibers bordering on the edge of the sinus node and the pacemaker area in the sinus node proper. When the pacing cycle length was increased and 1:1 atrio-sinus conduction was present, conduction time did not significantly differ from control. At this longer pacing cycle length the mean ERP of the sinus node was 380 msec greater than control and lasted well after repolarization was completed. Thus, atrio-sinus block during exposure to ACh 5 x 10~6 M resulted from a marked prolongation of refractoriness. Circ Res 44: 112-120, 1979

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“…Patients su!ering from arrhythmia originating in the SN area are said to have the &&sick sinus syndrome'' (Rubenstein et al, 1972;Ferrer, 1973;Kaplan et al, 1973;Jordan et al, 1978;Delon et al, 1992). In this syndrome, sinus rhythm is most often slower than normal, but there may be paroxysmal attacks of tachycardia or atrial "brillation.…”

Section: Introductionmentioning

confidence: 99%